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Flashcards in Transfusion Medicine Deck (24):
1

blood antigen vs antibody

antigen is on the blood cell, antibody is in the plasma serum

2

Blood group O

H antigen, anti-A/B antibodies. O-=universal blood cell donor, universal plasma recipient. can only receive O blood.

3

Blood group A

A antigen, anti-B serum antibody. can receive A & O blood/plasma

4

Blood group B

B antigen, anti-A serum antibody. Can receive B & O blood.

5

Blood group AB

A/B antigens, no serum antibodies. AB+=universal blood recipient, universal plasma donor. can only receive AB plasma

6

most common blood type?

O

7

where are ABO antigens located?

on all body tissues. need to be tested before any type of transplant

8

hemolytic disease of the newborn

Rh- mother has a Rh+ baby. At delivery, she gets exposed to Rh+ red cells of baby and begins producing Rh+ antibodies, which can cause anemia, hepato/splenomegaly, brain damage in next Rh+ baby

9

treatment for hemolytic disease of newborn?

Rhogam, a concentrated anti-Rh antibody.
dose Rh- mother at 28 weeks and then again at birth if newborn is Rh+. or at any point of trauma during the pregnancy

10

packed RBC effect

one unit raised Hgb 1-1.5 g/dL

11

platelet infusion effect

one unit raises count 5-10,000

12

crossmatch

the final checkpoint in compatibility testing for transfusions. take cells from donation bag and mix with patients serum to ensure no agglutination occurs

13

top 3 causes of transfusion related fatality

acute hemolytic transfusion run (usually due to clerical error), bacterial contamination of platelets, TRALI (pulmonary edema)

14

hemolytic transfusion rxn of ABO group

ABO antigens induce naturally occurring IgM antibodies to destroy transfused cells by fixing complement and causing intravascular hemolysis

15

Rh antibodies

not naturally occurring. only present if Rh- person has been exposed to the antigen through pregnancy or transfusion.

16

hemolytic transfusion run of Rh(D)

anti-Rh(D) is IgG and destroys transfused RBCs by reticule-endothelial phagocytosis mediated by Fc and complement receptors (extravascular hemolysis)

17

Coombs tests for blood type

Direct for ABO groups. IgM is large enough to bridge two RBCs.
Indirect for Rh(D0. IgG too small to bridge two RBCs, so patients serum is used and RBCs are added

18

hemolytic disease of the newborn caused by IgG to Rh(D)

erythroblastosis fetalis

19

forward typing

test patient's RBCs for antigen by adding anti-A/B/D.

20

Reverse typing

test patients serum for antibodies. if anti-A is present, will agglutinate with A cells and patient is either B or O

21

antibody screen

tests for alloantibodies to RBC antigens. serum from patient is incubated with screening cells that have known antigens and then run through a medium with antigens. if alloantibodies are present, will not move through medium to bottom

22

direct antiglobulin test (DAT)

Direct Coombs Test. used to detect antibodies that are stuck to the surface of patients red blood cells.

23

indirect coombs test (IAT)

looks for free-flowing antibodies against certain red blood cells. tests patients serum with reagent red cells.

24

which blood type is most common?

O