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Flashcards in Alzheimer's Disease Deck (6)
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1
Q

What are the abnormal proteins that aggregate for each of the 4 dementias?

A

AD = Amyloid B-42
Fronto Temporal Dementia = Tau
Dementia with lewy bodies = alpha-synuclein
CJD = prion

2
Q

What are the sporadic risk factors that are linked to dementias?

A

Head trauma, stroke, HTN, Diabetes, high cholesterol, low exercise, AGE

3
Q

What are the characteristic gross and histological signs of AD?

A

Neuritic plaques
Neurofibrillary tangles
Synaptic and neuronal loss due to apoptosis
Brain atrophy

4
Q

What are early signs of AD?

A

gradual failure of episodic memory

anosmia

5
Q

What are neuritic plaques?

A

Extracellular deposits of insoluble fibrils of polymers of amyloid-beta proteins.

6
Q

What is the amyloid hypothesis?

A

Extracellular accumulation of neuritic plaques leads to disruption of synaptic transmission.