Amino Acid-Base Chemistry (5/10) Flashcards
1
Q
Which functional groups contribute to the acid-base chemistry of proteins>
A
c-terminal, N-terminal and side-chain carboxylic acids
2
Q
Describing acid-base properties of an amino acid
A
Diprotic, Triprotic, and polyprotic
3
Q
Protonation and deprotonation
A
Bronsted-lowery definition
4
Q
Good rule
A
pHpKa= deprotonation
5
Q
pH=pKa
A
when 50% is deprotonated and 50% is protonated
6
Q
Flat point
A
Resists changes in pH
7
Q
At first equivalence point
A
mole of base added = moles of acid
8
Q
Half equivalence point
A
50% 50% protonated and deprotonated
9
Q
Isoelectric point
A
want a zero net charge
between 2 pKa values (halfway)
10
Q
Finding isoelectric point for basic amino acids
A
between second and third pKa
11
Q
Finding isoelectric point for acidic amino acids
A
First two pKa’s (lowest pKa’s)
