Glycogen Metabolism and the Pentose Phosphate Pathway (5/16)

Question 1

Glycogen phosphorylase

Answer 1

Does the cleavage of alpha 1,4 glycosidic bonds between two glucose units

Question 2

What bonds does glycogen contain?

Answer 2

alpha 1,4 and alpha 1,6

Question 3

In gluconeogensis, what is the order in which Phosphoglucomutase, glycogen debranching enzyme, glycogen phosphorylase acts?

Answer 3

Glycogen phosphorylase
phosphoglucomutase- convers G1P to G6P
glycogen debranching enzyme

Question 4

Where is glycogen mainly storred?

Answer 4

Hepatocytes and skeletal muscle

Question 5

Role of insulin in glycogen synthesis

Answer 5

it does not directly activate glycogen synthase. it rather inhibits the inhibitor

Question 6

Goal of the pentose phosphate pathway

Answer 6

Goal: taking glucose and NADP+ and creating ribose 5-phosphate and NADPH
NADPH= reducing agent

Question 7

Oxidative phase/decarboxylation

Answer 7

G6P –> 6-phosphogluconolactone by G6P dehydrogenase (rate limiting to make one NADPH) –> 6-phosphoglucanate –> ribulose 5-phosphate (produce another NADPH and CO2) –> ribose 5-phosphate

Question 8

Nonoxidative phase

Answer 8

recycles to make G6P because we do not need all the energy that the oxidative phase makes
6 x ribose 5-phosphate –> 5 x fructose 6-phosphate –> G6P
30 total carbons get rearranged