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Pharmacology > Anti-arrhythmic drugs > Flashcards

Anti-arrhythmic drugs Flashcards

1
Q

What are the class I anti arrhythmic agents?

A

Na+ channel blockers (local anesthesia)

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2
Q

What are the class II drugs?

A

beta blockers

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3
Q

What are the class 3 drugs?

A

prolong AP and refractory period

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4
Q

What are the class 4 drugs?

A

calcium channel blockers

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5
Q

What are examples of class IA anti-arrhythmics?

A

IA: procainamide, quinidine, disopyramide

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6
Q

What are class IB?

A

lidocaine, mexiletine

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7
Q

What are class IC?

A

flecainide, propafenone

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8
Q

What are examples of class II drugs?

A

propanolol, esmolol

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9
Q

What are examples of class III drugs

A

amiodarone
dronedarone
sotalol

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10
Q

What is the MOA of procainamide

A

block Na and K channels slowing the upstroke of AP conduction and prolonging QRS

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11
Q

What is the clinical application?

A

atrial and ventricular arrhythmias

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12
Q

How does quinidine differ from procainamide?

A

stronger anticholinergic effects but rarely used due to cardiac and extra cardiac adverse effects

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13
Q

Which class IA drug has the greatest anticholinergic effects?

A

disopyramide

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14
Q

What effect does hypokalemia have on the heart?

A

raises slope of depolarization (increases heart rate)

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15
Q

True or false: all cardiac cells can show pacemaker activity

A

true

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16
Q

What are the 3 requirements for re-entry?

A

1) blockage
2) unidirectional conduction
3) slow conduction through the block

17
Q

What are 4 potential goals of anti-arrhythmic drugs?

A

1) reduction of phase 4 slope
2) increase of max Em
3) increase of threshold potential
4) increase of AP duration

18
Q

What is the goal of anti-arrhythmics from a Na+ channel standpoint?

A

prolong the recovert time of Na channels

19
Q

What is the danger of anti arrhythmics?

A

they do NOT act specifically and can depress conduction leading to drug induced arrhythmias

20
Q

What do you treat minimally symptomatic arrhythmias with?

A

NOTHING

21
Q

What is the DOC for treatment of vtach and fib after cardioversion of ischemia?

A

lidocaine

Pharmacology (21 decks)

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