Flashcards in Anti-arrhythmic drugs Deck (21)
What are the class I anti arrhythmic agents?
Na+ channel blockers (local anesthesia)
What are the class II drugs?
What are the class 3 drugs?
prolong AP and refractory period
What are the class 4 drugs?
calcium channel blockers
What are examples of class IA anti-arrhythmics?
IA: procainamide, quinidine, disopyramide
What are class IB?
What are class IC?
What are examples of class II drugs?
What are examples of class III drugs
What is the MOA of procainamide
block Na and K channels slowing the upstroke of AP conduction and prolonging QRS
What is the clinical application?
atrial and ventricular arrhythmias
How does quinidine differ from procainamide?
stronger anticholinergic effects but rarely used due to cardiac and extra cardiac adverse effects
Which class IA drug has the greatest anticholinergic effects?
What effect does hypokalemia have on the heart?
raises slope of depolarization (increases heart rate)
True or false: all cardiac cells can show pacemaker activity
What are the 3 requirements for re-entry?
2) unidirectional conduction
3) slow conduction through the block
What are 4 potential goals of anti-arrhythmic drugs?
1) reduction of phase 4 slope
2) increase of max Em
3) increase of threshold potential
4) increase of AP duration
What is the goal of anti-arrhythmics from a Na+ channel standpoint?
prolong the recovert time of Na channels
What is the danger of anti arrhythmics?
they do NOT act specifically and can depress conduction leading to drug induced arrhythmias
What do you treat minimally symptomatic arrhythmias with?