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Flashcards in Anti-arrhythmic drugs Deck (21)
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1

What are the class I anti arrhythmic agents?

Na+ channel blockers (local anesthesia)

2

What are the class II drugs?

beta blockers

3

What are the class 3 drugs?

prolong AP and refractory period

4

What are the class 4 drugs?

calcium channel blockers

5

What are examples of class IA anti-arrhythmics?

IA: procainamide, quinidine, disopyramide

6

What are class IB?

lidocaine, mexiletine

7

What are class IC?

flecainide, propafenone

8

What are examples of class II drugs?

propanolol, esmolol

9

What are examples of class III drugs

amiodarone
dronedarone
sotalol

10

What is the MOA of procainamide

block Na and K channels slowing the upstroke of AP conduction and prolonging QRS

11

What is the clinical application?

atrial and ventricular arrhythmias

12

How does quinidine differ from procainamide?

stronger anticholinergic effects but rarely used due to cardiac and extra cardiac adverse effects

13

Which class IA drug has the greatest anticholinergic effects?

disopyramide

14

What effect does hypokalemia have on the heart?

raises slope of depolarization (increases heart rate)

15

True or false: all cardiac cells can show pacemaker activity

true

16

What are the 3 requirements for re-entry?

1) blockage
2) unidirectional conduction
3) slow conduction through the block

17

What are 4 potential goals of anti-arrhythmic drugs?

1) reduction of phase 4 slope
2) increase of max Em
3) increase of threshold potential
4) increase of AP duration

18

What is the goal of anti-arrhythmics from a Na+ channel standpoint?

prolong the recovert time of Na channels

19

What is the danger of anti arrhythmics?

they do NOT act specifically and can depress conduction leading to drug induced arrhythmias

20

What do you treat minimally symptomatic arrhythmias with?

NOTHING

21

What is the DOC for treatment of vtach and fib after cardioversion of ischemia?

lidocaine