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Flashcards in General Anesthetics Deck (22)
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1

How do anesthetics work?

GABAa chloride channel IPSP

GABA stimulates chloride channel to open making cell hyperpolarized (inhibiting APs)

2

What is MAC?

minimal alveolar concentration at 1ATM that prevents movement during skin incision in 50%

3

What is the MAC formula to achieve preventing movement in 95% people?

1.3 x MAC

4

What 3 factors influence MAC?

temp
age
prescriptions

5

What 4 factors do NOT influence MAC?

sex
O2
pH
BP

6

As cardiac output increases, what happens to induction with inhalation anesthetics?

GETS SLOWER

(inverse relationship with CO)

7

What is the equation for anesthesia?

FA/FI

(end-tidal/inspired)

8

True or false: the faster the agent gets from one compartment to the next, the slower it reaches equilibrium

TRUE

9

What 3 factors determine GA uptake from the blood?

1) solubility
2) partial pressure difference
3) cardiac output

10

Define FA

the end tidal partial pressure is the brain partial pressure

11

Which drug is more soluble in the blood, NO or Halothane?

HALOTHANE

12

Which achieves equilibrium faster, NO or halothane?

NO (blood cannot hold that much NO)

13

Which blood compartment is larger, NO or halothane?

halothane (holds more since drug is more soluble)

14

What does a larger blood/gas partition coefficient mean?

more soluble
takes longer to reach equilibrium
larger blood compartment

15

What are the vessel rich organs? BHLK

brain
heart
lung
kidney

16

Increased blood flow near alveolus _______ (slows/speeds up) equilibrium because it increases uptake

slows

remember: cerebral blood flow is regulated so an increase in CO should not bring extra agent to brain

17

What effect does GA have on lungs?

bronchodilation

18

What happens to the brain during GA?

uncoupling
(increased blood flow but decreased O2 consumption)

19

What IV anesthetic is used for induction, maintenance, sedation in the OR or ICU?

propofol

mechanism: IPSP

increases intracranial pressure

20

What was the most used induction agent before propofol?

thiopental

arterial vasoconstrictor

21

What are some of the good effects of ketamine?

1) dissociative anesthesia
2) bronchodilator, keep breathing
3) increase BP and HR
4) increase ICP and cerebral blood flow

22

What is the hallmark of etomidate?

least cardiovascular side effects