Cephalosporins, Carbapenems, Monobactams Flashcards Preview

Pharmacology > Cephalosporins, Carbapenems, Monobactams > Flashcards

Flashcards in Cephalosporins, Carbapenems, Monobactams Deck (20)
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1

First generation cephalosporins

cephalexin
cefazolin

2

Second generation cephalosporins

Cefuroxime
cefprozil
cefoxitin
cefotetan

3

What are the ONLY cephalosporins that have activity against ANAEROBES

cephamycins

(2nd generation)

4

What is the target org of ceftazidime and cefoperazone?

pseudomonas

5

What do the 3rd generation cephalosporins cover?

GRAM NEG aerobes

6

What is the only 4th generation cephalosporin?

cefepime

7

What are the 2 reasons for 4th generation cephalosporins

1) extended SOA
2) stable against beta lactamases

8

Most cephalosporins are eliminated by _____________ but ceftriaxone is eliminate by ________ and cefoperazone __________

kidney

bile

liver

9

What is an unexpected clinical use of 1st generation cephalosporins?

surgical prophylaxis

10

What 2 cephalosporins cover pseudomonas?

ceftazidime (3rd)
cefepime (4th)

11

What are the clinical uses of cetriaxone?

gonorrhea, CAP, PRSP, viridans

12

What are the 4 carbapenems?

imipenem
meropenem
ertapenem
doripenem

13

What are the most broad spectrum agents out there?

carbapenems

14

What is the only carbapenem that does not cover pseudomonas?

ertapenem

15

What is a target organism of carbapenems?

bacteroides

16

Where are carbapenems eliminated?

kidney (imipenem at brush border)

17

What are the clinical uses for carbapenem?

1) HA infections
2) polymicrobe infections
3) infections due to beta lactamase producing orgs
4) pseudomonas but NOT ertapenem

18

What is the only monobactam?

aztreonam

19

What is the target of aztreonam?

pseudomonas

(ONLY GRAM NEG AEROBES)

20

Can you use aztreonam in penicillin allergy patients?

YES no cross reactivity