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Pharmacology > Cephalosporins, Carbapenems, Monobactams > Flashcards

Cephalosporins, Carbapenems, Monobactams Flashcards

1
Q

First generation cephalosporins

A

cephalexin

cefazolin

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2
Q

Second generation cephalosporins

A

Cefuroxime
cefprozil
cefoxitin
cefotetan

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3
Q

What are the ONLY cephalosporins that have activity against ANAEROBES

A

cephamycins

2nd generation

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4
Q

What is the target org of ceftazidime and cefoperazone?

A

pseudomonas

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5
Q

What do the 3rd generation cephalosporins cover?

A

GRAM NEG aerobes

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6
Q

What is the only 4th generation cephalosporin?

A

cefepime

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7
Q

What are the 2 reasons for 4th generation cephalosporins

A

1) extended SOA

2) stable against beta lactamases

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8
Q

Most cephalosporins are eliminated by _____________ but ceftriaxone is eliminate by ________ and cefoperazone __________

A

kidney

bile

liver

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9
Q

What is an unexpected clinical use of 1st generation cephalosporins?

A

surgical prophylaxis

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10
Q

What 2 cephalosporins cover pseudomonas?

A

ceftazidime (3rd)

cefepime (4th)

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11
Q

What are the clinical uses of cetriaxone?

A

gonorrhea, CAP, PRSP, viridans

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12
Q

What are the 4 carbapenems?

A

imipenem
meropenem
ertapenem
doripenem

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13
Q

What are the most broad spectrum agents out there?

A

carbapenems

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14
Q

What is the only carbapenem that does not cover pseudomonas?

A

ertapenem

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15
Q

What is a target organism of carbapenems?

A

bacteroides

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16
Q

Where are carbapenems eliminated?

A

kidney (imipenem at brush border)

17
Q

What are the clinical uses for carbapenem?

A

1) HA infections
2) polymicrobe infections
3) infections due to beta lactamase producing orgs
4) pseudomonas but NOT ertapenem

18
Q

What is the only monobactam?

A

aztreonam

19
Q

What is the target of aztreonam?

A

pseudomonas

ONLY GRAM NEG AEROBES

20
Q

Can you use aztreonam in penicillin allergy patients?

A

YES no cross reactivity

Pharmacology (21 decks)

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