Protein synthesis inhibitors Flashcards Preview

Pharmacology > Protein synthesis inhibitors > Flashcards

Flashcards in Protein synthesis inhibitors Deck (13)
Loading flashcards...
1

What is the MOA of clindamycin?

binds to 50S subunit (can cause competitive competition with macrolides)

2

Is Clindamycin bacteriostatic or cidal?

STATIC but cidal at high conc

3

What are 3 MORs of clindamycin?

1) altered target sites
2) active efflux
3) low level resistance to macrolides

4

What is the SOA of clindamycin?

GRAM POS AEROBES: MSSA, PSSP, group/viridans strep

ANAEROBES: bacteroides

5

How is clindamycin administered?

IV or PO (good bioavailability/absorption)

6

How is clindamycin eliminated?

liver (not HD)

7

When do you use clindamycin?

anaerobic infections OUTSIDE CNS (like pulm, intraab, pelvic, diabetic foot, ulcer)
SSTIs
alternative

8

What are the main adverse effects of clindamycin?

1) GI
2) C. diff inducer
3) hepatotoxicty

9

What are the 3 macrolides?

erythromycin
clarithromycin
azithromycin

10

What is the MOA of macrolides?

inhibit prot synth by binding to 50S subunit

11

are macrolides time or conc dependent?

erythro and clathro - time dependent
azithro - conc dependent

12

What are the MORs for macrolides?

1) efflux pump
2) altered target sites
3) cross resistance

13

What is the macrolide SOA?

Gram pos: clarithro>erythro>azithro