Protein synthesis inhibitors Flashcards

1
Q

What is the MOA of clindamycin?

A

binds to 50S subunit (can cause competitive competition with macrolides)

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2
Q

Is Clindamycin bacteriostatic or cidal?

A

STATIC but cidal at high conc

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3
Q

What are 3 MORs of clindamycin?

A

1) altered target sites
2) active efflux
3) low level resistance to macrolides

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4
Q

What is the SOA of clindamycin?

A

GRAM POS AEROBES: MSSA, PSSP, group/viridans strep

ANAEROBES: bacteroides

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5
Q

How is clindamycin administered?

A

IV or PO (good bioavailability/absorption)

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6
Q

How is clindamycin eliminated?

A

liver (not HD)

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7
Q

When do you use clindamycin?

A

anaerobic infections OUTSIDE CNS (like pulm, intraab, pelvic, diabetic foot, ulcer)
SSTIs
alternative

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8
Q

What are the main adverse effects of clindamycin?

A

1) GI
2) C. diff inducer
3) hepatotoxicty

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9
Q

What are the 3 macrolides?

A

erythromycin
clarithromycin
azithromycin

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10
Q

What is the MOA of macrolides?

A

inhibit prot synth by binding to 50S subunit

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11
Q

are macrolides time or conc dependent?

A

erythro and clathro - time dependent

azithro - conc dependent

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12
Q

What are the MORs for macrolides?

A

1) efflux pump
2) altered target sites
3) cross resistance

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13
Q

What is the macrolide SOA?

A

Gram pos: clarithro>erythro>azithro

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