Flashcards in Protein synthesis inhibitors Deck (13)
What is the MOA of clindamycin?
binds to 50S subunit (can cause competitive competition with macrolides)
Is Clindamycin bacteriostatic or cidal?
STATIC but cidal at high conc
What are 3 MORs of clindamycin?
1) altered target sites
2) active efflux
3) low level resistance to macrolides
What is the SOA of clindamycin?
GRAM POS AEROBES: MSSA, PSSP, group/viridans strep
How is clindamycin administered?
IV or PO (good bioavailability/absorption)
How is clindamycin eliminated?
liver (not HD)
When do you use clindamycin?
anaerobic infections OUTSIDE CNS (like pulm, intraab, pelvic, diabetic foot, ulcer)
What are the main adverse effects of clindamycin?
2) C. diff inducer
What are the 3 macrolides?
What is the MOA of macrolides?
inhibit prot synth by binding to 50S subunit
are macrolides time or conc dependent?
erythro and clathro - time dependent
azithro - conc dependent
What are the MORs for macrolides?
1) efflux pump
2) altered target sites
3) cross resistance