Anti-Cancer

Question 1

which drugs are nitrogen mustards

Answer 1

chlorambucil
cyclophosphamide
melphalan

Question 2

which nitrogen mustard is used for chronic lymphocytic leukemia and mast cells

Answer 2

chorambucil

Question 3

in what species would you want to combine chlorambucil with sterioids

Answer 3

cats

Question 4

what drug should be used for GI lymphoma in cats

Answer 4

chlorambucil

Question 5

a cat comes in with a loss of whiskers. which drug was he probable on

Answer 5

chlorambucil

Question 6

what cytotoxic agent causes sterile hemorrhagic cysts

Answer 6

acrolein
cyclophosphamide

Question 7

what drug is used to treat the sterile hemorrhagic cyst

Answer 7

furosemide

Question 8

hwo does chlorambucil affect tumor growth

Answer 8

slows them down

Question 9

what is needed to convery cyclophosphamide to its active form

Answer 9

cyclophosphamide

Question 10

what is cycylophosphamide used to treat in cats

Answer 10

lymphoma

Question 11

what is cyclophosphamide used to treat in dogs

Answer 11

lymphoma
malignant mammary gland tumors

Question 12

what are the adverse effects shared by chlorambucil and cyclophosphamide

Answer 12

GI toxicity in cats
alopecia
myelosuppression
neutropenia
thrombocytopenia

Question 13

what nitrogen mustard is used as a rescue drug to treat relapsed lymphoma dogs

Answer 13

melphalan

Question 14

what is the adverse effect of melphalan

Answer 14

delayed thrombocytopenia

Question 15

which nitrosoureas drug crosses the blood brain barrier

Answer 15

lomustine

Question 16

what are the adverse effects of lomustine

Answer 16

bone marrow depression
hepatotoxicity

Question 17

what is the main use of lomustine due to its ability to cross the blood brain barrier

Answer 17

brain tumors

Question 18

other than brain tumors, what else can lomustine be used for

Answer 18

histiocytic sarcomas
mast cells
epitheliotropic and refractory lymphomas

Question 19

which drugs are platinum compounds

Answer 19

cisplatin
carboplatin

Question 20

what is downfall of the platinum compounds

Answer 20

resistance to the drugs can occur through inactivation and increased repair

Question 21

how are the platinum compounds administered

Answer 21

IV

Question 22

which platinum compound is combined with doxorubicin

Answer 22

carbplatin

Question 23

which platinum compound is used for squamous cell carcinoma, osteosarcomas, transitional cell carinomas and nasal adenocarcinomas

Answer 23

cisplatin

Question 24

what is carboplatin used for

Answer 24

canine appendicular osteosarcoma
carcinomas

Question 25

in general what are the platinum compounds used for

Answer 25

carcinomas

Question 26

what are some concerns to be aware of when administering cisplatin

Answer 26

nephrotoxicity emesis do not used in cats

Question 27

what are some concerns to be aware of when administering carboplatin

Answer 27

myelosuppression less nephrotoxicity and emesis

Question 28

which drugs can be used to treat intracranial lymphomas and lymphoma and leukemia in combination

Answer 28

cytarabine

Question 29

what can be combined with cytarabine to treat meningoencephalitis

Answer 29

prednisolone

Question 30

how is cytarabine administered

Answer 30

SQ CRI

Question 31

what are the adverse effects of cytarabine

Answer 31

myelopsuppression GI upset

Question 32

which drug should be used to treat sarcoid in horses and spindle cell tumors in dogs

Answer 32

5-fluorouracil

Question 33

how is 5-fluorouracil administered

Answer 33

local topical

Question 34

how does 5-fluorouracil affect dogs

Answer 34

myelosuppression GI toxicity neurotoxicity

Question 35

in what species should 5-fluroruracil not be used in

Answer 35

cats

Question 36

which drug can see resistance due to upregulation of MDR1

Answer 36

doxorubucin mitoxantrone

Question 37

how is doxorubucin administered

Answer 37

IV only

Question 38

which drug is considered broad spectrum

Answer 38

doxorubicin

Question 39

what dog breeds are contraindicated with doxorubicin due to worse cardiotoxicity

Answer 39

dobermans boxers

Question 40

what are the adverse effects of doxorubucin

Answer 40

myelosuppression GI toxicity cardiotoxicity severe tissue necrosis renal tubular damage in cats acute anaphylaxis

Question 41

what can be combine with doxorubicin

Answer 41

carboplatin

Question 42

which drug is used for lymphomas leukemias and transitional cell carcinoma of bladder

Answer 42

mitoxantrone

Question 43

which cytotoxic antibiotic should not be used with radiotherapy

Answer 43

doxorubicin mitoxantrone

Question 44

why is mitoxantrone a better cytotoxic antibiotic

Answer 44

no cardiotoxicity or tissue necrosis

Question 45

which drugs are plant derivatives

Answer 45

vincristine vinbalstine paclitaxel

Question 46

which drugs see resisitance due to tubulin binding

Answer 46

vincristine vinblastine

Question 47

what is vinblastine used for in dogs

Answer 47

mast cell tumors

Question 48

what is vincristine used for

Answer 48

lymphoma TVT

Question 49

what drugs cross resist with vincristine and vinblastine

Answer 49

doxorubicin mitoxantrone

Question 50

what is paclitaxel used for

Answer 50

osteosarcomas mammary carcinomas malignant histiocytomas

Question 51

which antineoplastic drug has a rapidly developing resistance

Answer 51

L-asparaginase

Question 52

what is L-asaparaginase used for

Answer 52

lymphoid malignancies

Question 53

which drug is used for anal sac adenocarcinomas

Answer 53

toceranib