Anti-cholinergic Drugs Flashcards Preview

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Flashcards in Anti-cholinergic Drugs Deck (21):
1

Muscarinic Receptor Blockers

1. Atropine 2. Homoatropine (short-acting prep of atropine) 3. Tropicamide (shortest acting prep of atropine, 4h) 4. Pirenzepine (tx peptic ulcers) 5. Scopolamine (prevents motion sickness) 6. Benztropine (tx druv induced Parkinsons 7. Ipratropium bromide (tx COPD & asthma) 8. Dicyclomide (tx mentral pain & GI spasm)

2

N receptor Blockers

1. Hexamethonium 2. Mecamylamine these competitively block NN receptors

3

Atropine

tertiary amine; enters CNS-->produces long-acting side effects 1. Decreased salivary, bronchial & sweat secretion-->dry mouth 2. mydriasis & cycloplegia-->loss of accommodation reflex 3. tachycardia 4. constipation 5. urinary retention 6. bronchial relaxation 7. excitation/hallucinations OPPOSITE TO DUMBBELSS

4

Tropicamide use

preferred to produce mydriasis & cycloplegia in refraction error testing & fundoscopy bc of 4h DOA

5

Benztropine use

DOC for treatment of drug-induced parkinsonism (tx extrapyramidal symptoms)

6

Ipratripium Bromide use

Tx COPD & Bronchial asthma (not much systemic absorption, so fewer side effects)

7

atropine poisoning effect on eye

1. mydriasis (iris practically obliterated) 2. blurring of near vision 3. dryness of conjunctiva

8

Pirenzepine use

Tx peptic ulcers

9

Scopolamine use

prevent motion sickness (other drugs used to treat motion sickness are antihistamine drugs)

10

Glycopyrrolate use

used in general anesthesia to reduce bronchial secretions

11

dicyclomine use

to treat GI spasm, spasmodic abdominal pain, i.e. menstrual pain (can also be treated using NSAIDS)

12

mydriasis (iris practically obliterated), blurring of near vision, dryness of conjunctiva, difficulty speaking, dyspnea, respiratory depression, dry, hot, red skin, dry mouth, thirst, difficulty swallowing, absence of bowel sounds, paralytic ileum, difficulty in micturition, tachycardia, palpitations, arrhythmias, fatigue, ataxia, headache, restlessness, hallucinations, delirium, generalized convulsions, coma

symptoms of atropine poisoning, aka Anti-DUMBBELSS Atropine = muscarinic receptor blocker

13

atropine poisoning effect on respiratory system

difficulty speaking, dyspnea, respiratory depression

14

atropine poisoning effect on skin

DRY, HOT, RED SKIN

15

atropine poisoning effect on GI system

1. dry mouth 2. thirst 3. difficulty swallowing 4. absence of bowel sounds 5. paralytic ileus

16

atropine poisoning effect on urinary system

difficulty in micturation

17

atropine poisoning effect on CVS

tachycardia, palpitations, arrhythmias

18

atropine poisoning effect on CNS

1. fatigue 2. ataxia 3. headache 4. restlessness 5. hallucinations 6. delirium 7. generalized convulsions 8. coma

19

Atropine uses

1. treat cholinesterase inhibitors/OP poisoning 2. treat poisoning by AChE inhibitors of by certain mushrooms containing muscarine 3. produce mydriases in refraction error testing (short acting preps of atropine are preferred 4. Treat Heart block 5. Treat Bradycardia

20

Hexamethonium, MOA, use

NN blocker, aka ganglion blocker MOA= competitive blockade of NN receptor Use: none due to high toxicity (SEVERE HYPOTENSION)

21

Mecamylamine, MOA, use

NN blocker, aka ganglion blocker MOA= competitive blockade of NN receptor Use: none due to high toxicity (SEVERE HYPOTENSION)