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Flashcards in Block 2 Drugs Deck (132)
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1

aspirin MOA

inhibit COX 1 (acetyaltes COX)-->inhibit TXA2 synthesis--> inhibit platelet aggregation

2

diphenhydramine
1. receptor
2. what generation?
3. use
4. AE

1. H1 receptor
2. 1st generation drug
3. use in allergic reactions, motion sickeness, EPS caused by antipsychotics
4. AE: anticholinergic affects (dry mouth, blurred vision, urinary hesitancy)

3

eptafibatide MOA

inhibit fibrinogen receptor

ie GpIIb/IIIa receptors

4

cetirizine

1. H1 receptor
2. 2nd generation drug
3. Use: allergic reactions; motion sickness, EPS caused by antipsychotics
4. AE: no sedation; no anticholinergic side effects

5

This drug causes neutropenia & TCP and is used as an alternative to aspirin

Ticlopidine

6

Dipyrimadole MOA

Inhibit PDE --> Inceases cAMP

7

abciximab MOA & uses

inhibit fibrinogen receptor

ie GpIIb/IIIa receptors

use: in coronary angioplasty with aspirin

8

tirofiban MOA

inhibit fibrinogen receptor

ie GpIIb/IIIa receptors

9

Promethazine
1. receptor
2. what generation?
3. use
4. AE

1. H1 receptor
2. 1st generation drug
3. use in allergic reactions, motion sickeness, EPS caused by antipsychotics
4. AE: anticholinergic affects (dry mouth, blurred vision, urinary hesitancy)

10

sumatriptan: type; receptor; use

AGONIST
5HT1D
receptor: 5HT1
use: acute migraine

11

tegaserid use

irritable bowel syndrome with constipation

12

chlorpheniramine
1. receptor
2. what generation?
3. use
4. AE

1. H1 receptor
2. 1st generation drug
3. use in allergic reactions, motion sickeness, EPS caused by antipsychotics
4. AE: anticholinergic affects (dry mouth, blurred vision, urinary hesitancy)

13

streptokinase MOA & use & AE

plasminogen-->plasmin-->fibrin

binds to free plasminogen. Very effective if given within 12-24h

AE: bleeding, treat by aminocaproic acid, tranexemic acid

14

cimetidine
type of drug
use
A/E

H2 receptor agonist
use: peptic ulcers; ZE syndrome; GERD
A/E: CYP enzyme inhibitor-->drug interactions

15

buspirone

agonist
5HT1a
use: anxiety disorder

16

Clopidogrel MOA

Inhibit ADP receptors--> increases cAMP

17

fexofenadine
1. receptor
2. what generation?
3. use
4. AE

1. H1 receptor
2. 2nd generation drug
3. Use: allergic reactions; motion sickness, EPS caused by antipsychotics
4. AE: no sedation; no anticholinergic side effects

18

alprostadil

PGE1
vasodilation
use: erectile dysfunction; potency of the ductus arterioles

19

aminocaproic acid, tranexemic acid

used to treat bleeding caused by streptokinase or alteplase (tPA)

20

LSD

5HT1 receptor agonist
is an ergot alkaloid
use: hallucinogen

21

Ticlopidine MOA & side effects

Inhibit ADP receptors--> increases cAMP

AE: can cause neutropenia & TCP

22

carboprost

PGF2alpha
effect: contraction of uterine muscle
use: abortifacent; postpartum bleeding

23

ketanserine

5HT2 receptor antagonist

24

alteplase (tPA)

binds to fibrin bound plasminogen

Very effective if given within 12-24h

AE: bleeding, treat by aminocaproic acid, tranexemic acid

25

dinoprostone

PGE2
effect: contraction of uterine muscle
use: abortifacient; cervical ripening

26

ranitidine

H2 receptor agonist
use: peptic ulcers; ZE syndrome; GERD

27

cyproheptadine

5HT2 receptor antagonist
use: carcinoid tumor

28

Hydroxyzine
1. receptor
2. what generation?
3. use
4. AE

1. H1 receptor
2. 1st generation drug
3. use in allergic reactions, motion sickeness, EPS caused by antipsychotics
4. AE: anticholinergic affects (dry mouth, blurred vision, urinary hesitancy)

29

epoprostenol

PGI2
effect: vasodilation
use: pulmonary hypertension

30

famotidine

H2 receptor agonist
use: peptic ulcers; ZE syndrome; GERD