Flashcards in Block 2 Drugs Deck (132)
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1
aspirin MOA
inhibit COX 1 (acetyaltes COX)-->inhibit TXA2 synthesis--> inhibit platelet aggregation
2
diphenhydramine
1. receptor
2. what generation?
3. use
4. AE
1. H1 receptor
2. 1st generation drug
3. use in allergic reactions, motion sickeness, EPS caused by antipsychotics
4. AE: anticholinergic affects (dry mouth, blurred vision, urinary hesitancy)
3
eptafibatide MOA
inhibit fibrinogen receptor
ie GpIIb/IIIa receptors
4
cetirizine
1. H1 receptor
2. 2nd generation drug
3. Use: allergic reactions; motion sickness, EPS caused by antipsychotics
4. AE: no sedation; no anticholinergic side effects
5
This drug causes neutropenia & TCP and is used as an alternative to aspirin
Ticlopidine
6
Dipyrimadole MOA
Inhibit PDE --> Inceases cAMP
7
abciximab MOA & uses
inhibit fibrinogen receptor
ie GpIIb/IIIa receptors
use: in coronary angioplasty with aspirin
8
tirofiban MOA
inhibit fibrinogen receptor
ie GpIIb/IIIa receptors
9
Promethazine
1. receptor
2. what generation?
3. use
4. AE
1. H1 receptor
2. 1st generation drug
3. use in allergic reactions, motion sickeness, EPS caused by antipsychotics
4. AE: anticholinergic affects (dry mouth, blurred vision, urinary hesitancy)
10
sumatriptan: type; receptor; use
AGONIST
5HT1D
receptor: 5HT1
use: acute migraine
11
tegaserid use
irritable bowel syndrome with constipation
12
chlorpheniramine
1. receptor
2. what generation?
3. use
4. AE
1. H1 receptor
2. 1st generation drug
3. use in allergic reactions, motion sickeness, EPS caused by antipsychotics
4. AE: anticholinergic affects (dry mouth, blurred vision, urinary hesitancy)
13
streptokinase MOA & use & AE
plasminogen-->plasmin-->fibrin
binds to free plasminogen. Very effective if given within 12-24h
AE: bleeding, treat by aminocaproic acid, tranexemic acid
14
cimetidine
type of drug
use
A/E
H2 receptor agonist
use: peptic ulcers; ZE syndrome; GERD
A/E: CYP enzyme inhibitor-->drug interactions
15
buspirone
agonist
5HT1a
use: anxiety disorder
16
Clopidogrel MOA
Inhibit ADP receptors--> increases cAMP
17
fexofenadine
1. receptor
2. what generation?
3. use
4. AE
1. H1 receptor
2. 2nd generation drug
3. Use: allergic reactions; motion sickness, EPS caused by antipsychotics
4. AE: no sedation; no anticholinergic side effects
18
alprostadil
PGE1
vasodilation
use: erectile dysfunction; potency of the ductus arterioles
19
aminocaproic acid, tranexemic acid
used to treat bleeding caused by streptokinase or alteplase (tPA)
20
LSD
5HT1 receptor agonist
is an ergot alkaloid
use: hallucinogen
21
Ticlopidine MOA & side effects
Inhibit ADP receptors--> increases cAMP
AE: can cause neutropenia & TCP
22
carboprost
PGF2alpha
effect: contraction of uterine muscle
use: abortifacent; postpartum bleeding
23
ketanserine
5HT2 receptor antagonist
24
alteplase (tPA)
binds to fibrin bound plasminogen
Very effective if given within 12-24h
AE: bleeding, treat by aminocaproic acid, tranexemic acid
25
dinoprostone
PGE2
effect: contraction of uterine muscle
use: abortifacient; cervical ripening
26
ranitidine
H2 receptor agonist
use: peptic ulcers; ZE syndrome; GERD
27
cyproheptadine
5HT2 receptor antagonist
use: carcinoid tumor
28
Hydroxyzine
1. receptor
2. what generation?
3. use
4. AE
1. H1 receptor
2. 1st generation drug
3. use in allergic reactions, motion sickeness, EPS caused by antipsychotics
4. AE: anticholinergic affects (dry mouth, blurred vision, urinary hesitancy)
29
epoprostenol
PGI2
effect: vasodilation
use: pulmonary hypertension
30
