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Flashcards in B2 Drug Names Deck (247)
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1

Ibuprofen

Reversibly inhibits Cox 1 and 2

2

Succinylcholine

Depolarizing NM blocker

3

Baclofen

Spasmalytic: GABA B agonist

increased K flow-->hyper polarization--> reduces release of excitatory NT

4

Simvastatin

Hypolipidemic: Competitive HMG-CoA reductase inhibitor (rate-limiting step of cholesterol synthesis) and induces high affinity LDL receptors--> reduces LDL levels

Toxicity = myositis and sometimes rhabdomyolysis (monitor creatine kinase) and hepatotoxicity (monitor liver enzymes)

Drugs that inhibit CYP enzymes will increase plasma concentrations of statins!!!

5

Cholestyramine

Bile Acid Binding Resin: Binds BA in intestine and forms complex that's excreted in feces.

Increased oxidation of cholesterol to BA in liver and increased # of LDL receptors--> decreased LDL levels and increased HDL

Toxicity: constipation, deficiency of fat-soluble vitamins (A, D, E, K)

May also delay or reduce the absorption of other oral medications (digitalis, warfarin)

CONTRAINDICATED in patients with hypertriglyceridemia

6

Gemfibrozil

HYPOlipidemic:

agonist at PPAR alpha and INCREASES the activity of LPL (esp in muscles and hepatocytes) --> hyperTG and reduces VLDL

Toxicity:
- GI symptoms
- myopathy
- cholesterol gallstones

Drug interactions: can displace other albumin-bound drugs like warfarin and sulfonyl ureas

7

D- Tubocurarine

Competitive Nm blocker

8

Bile acid binding resins are contraindicated in whom?

patients with hypertriglyceridemia

9

Tizanidine

alpha 2 agonist used as a spasmolytic --> decreases m tone without causing paralysis

10

pravastatin

Hypolipidemic: Competitive HMG-CoA reductase inhibitor (rate-limiting step of cholesterol synthesis) and induces high affinity LDL receptors--> reduces LDL levels

Toxicity = myositis and sometimes rhabdomyolysis (monitor creatine kinase) and hepatotoxicity (monitor liver enzymes)

Drugs that inhibit CYP enzymes will increase plasma concentrations of statins!!!

11

colestipol

Bile Acid Binding Resin: Binds BA in intestine and forms complex that's excreted in feces.

Increased oxidation of cholesterol to BA in liver and increased # of LDL receptors--> decreased LDL levels and increased HDL

Toxicity: constipation, deficiency of fat-soluble vitamins (A, D, E, K)

May also delay or reduce the absorption of other oral medications (digitalis, warfarin)

CONTRAINDICATED in patients with hypertriglyceridemia

12

Vecuronium

Competitive Nm blocker

13

Niacin

hypolipidemic: inhibition of VLDL synthesis and esterification of FA in liver --> decreased plasma LDL, VLDL and TG levels!

Toxicity:
- flushing
- itching (treated by aspirin or other NSAID)
- diarrhea
- hyperuricemia (gout)
- hyperglycemia

14

Using what drugs along with statins causes an increased risk of myopathy?

- amiodarone
- verapamil
- fibrates

15

Dantrolene

Tx malignant hyperthermia

inhibits release of Ca from SR during excitation/contraction coupling

also inhibits ryanodine receptor and Calcium channels in skeletal m

16

lovastatin

Hypolipidemic: Competitive HMG-CoA reductase inhibitor (rate-limiting step of cholesterol synthesis) and induces high affinity LDL receptors

--> reduces LDL levels

Toxicity = myositis and sometimes rhabdomyolysis (monitor creatine kinase) and hepatotoxicity (monitor liver enzymes)

Drugs that inhibit CYP enzymes will increase plasma concentrations of statins!!!

17

pancuronium

Competitive Nm blocker

18

colesevelam

Bile Acid Binding Resin: Binds BA in intestine and forms complex that's excreted in feces.

Increased oxidation of cholesterol to BA in liver and increased # of LDL receptors--> decreased LDL levels and increased HDL

Toxicity: constipation, deficiency of fat-soluble vitamins (A, D, E, K)

May also delay or reduce the absorption of other oral medications (digitalis, warfarin)

CONTRAINDICATED in patients with hypertriglyceridemia

19

How do you treat parities (itching) caused by Niacin?

aspirin or other NSAID

20

Gabapentin

spasmolytic

21

Fenofibrate

HYPOlipidemic:

agonist at PPAR alpha and INCREASES the activity of LPL (esp in muscles and hepatocytes) --> hyperTG and reduces VLDL

Toxicity:
- GI symptoms
- myopathy
- cholesterol gallstones

Drug interactions: can displace other albumin-bound drugs like warfarin and sulfonyl ureas

22

doxacurium

Competitive Nm blocker

23

Ezetimibe

HYPOlipidemic

reduces GI absorption of cholesterol--> reduces LDL and TG

Toxicity: diarrhea, abdominal pain

24

Vigabatrin

Anti-epileptic drug

MOA: irreversibly inhibits GABA transaminase (GTA)

25

Epinephrine

Bronchodilator (lasts 60-90m); rapid action

also used in anaphylactic shock (is a physiological antagonist)

Given Subcutaneous/Inhalation

--> tachycardia, arrhythmias

MOA: sympathetic stimulation of Beta2 receptor (adrenergic agonist)

A/E: skeletal m tremor, tachycardia, palpitations tolerance (short acting drugs)

26

Prednisolone

oral systemic corticosteroid

MOA: Has anti-inflammatory effects. Binds to an internuclear receptor and inhibits the transcription of genes that are responsible for producing cytokines. ESP interleukins

Use: severe chronic asthma

Chronic use can lead to Cushing's Disease

A/E:
- easy brushing
- adrenal suppression
- growth retardation
- increased bone catabolism--> osteoporosis

27

Rocuronium

Competitive Nm blocker

28

Tiotropium Bromide

Bronchodilator: given via inhalation; long acting (24h)

MOA: parasympathetic! Blockage of muscarinic receptors: anticholinergics

Blocks muscarinic receptors in large airways

frequently used in combo with salbutamol (DOC for people on beta blockers)

29

Tiagabine

Anti-epileptic drug

MOA: blocks GABA reuptake by blocking GAT (GABA transporter)

30

Isoproterenol

Bronchodilator

MOA: sympathetic stimulation of Beta2 receptor (adrenergic agonist)

A/E: skeletal m tremor, tachycardia, palpitations tolerance (short acting drugs)