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Flashcards in ANS Deck (146)
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1

How do muscarinic receptors act

they are G-protein coupled receptors

2

How to nicotinic receptors act

They are ion-channel mediated (increase Na+ movement into cells)

3

Types of nicotinic receptors

NM and NN

4

Effects of M2 receptors

Heart: reduce HR, FOC and CO

5

Effects of M3 receptors

1. blood vessel: vasodilation and and decrease BP 2. smooth muscle: contraction--> broncospasm, diarrhea, urination 3. Pupil: miosis 4. Glands: increase salivation (increase lacrimation), sweating, gastric acid

6

M1 receptor type

Gq

7

Effector enzyme at Gq

Gq-->stimulate PLC-->increase IP3 & DAG--> Increase Ca++ DAG remains bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particularly calcium channels in the smooth endoplasmic reticulum (ER). This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.[3] In addition, calcium and DAG together work to activate protein kinase C, which goes on to phosphorylate other molecules, leading to altered cellular activity.

8

Effector enzyme at M1

Gq-->stimulate PLC-->increase IP3 & DAG--> Increase Ca++ DAG remains bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particularly calcium channels in the smooth endoplasmic reticulum (ER). This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.[3] In addition, calcium and DAG together work to activate protein kinase C, which goes on to phosphorylate other molecules, leading to altered cellular activity.

9

M3 receptor type

Gq

10

Effector enzyme at alpha 1

Gq-->stimulate PLC-->increase IP3 & DAG--> Increase Ca++ DAG remains bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particularly calcium channels in the smooth endoplasmic reticulum (ER). This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.[3] In addition, calcium and DAG together work to activate protein kinase C, which goes on to phosphorylate other molecules, leading to altered cellular activity.

11

Effector enzyme at M3

Gq-->stimulate PLC-->increase IP3 & DAG--> Increase Ca++ DAG remains bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particularly calcium channels in the smooth endoplasmic reticulum (ER). This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.[3] In addition, calcium and DAG together work to activate protein kinase C, which goes on to phosphorylate other molecules, leading to altered cellular activity.

12

alpha 2 receptor type

Gi

13

Gq second messenger

stimulates PLC-->increase IP3 & DAG--> Increase Ca++ DAG remains bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particularly calcium channels in the smooth endoplasmic reticulum (ER). This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.[3] In addition, calcium and DAG together work to activate protein kinase C, which goes on to phosphorylate other molecules, leading to altered cellular activity.

14

alpha 1 receptor type

Gq

15

beta 1 effector enzyme

Gs-->stimulate adenylyl cyclase-->increase cAMP

16

M2 receptor type

Gi

17

Gi effector enzyme

Gi-->inhibit adenylyl cyclase-->decrease cAMP

18

alpha 2 effector enzyme

Gi-->inhibit adenylyl cyclase-->decrease cAMP

19

Receptors that act via Gs

beta 1, beta 2, beta 3

20

M2 effector enzyme

Gi-->inhibit adenylyl cyclase-->decrease cAMP

21

beta 2 effector enzyme

Gs-->stimulate adenylyl cyclase-->increase cAMP

22

Receptors that act via Gq

M1, M3 & alpha 1

23

beta 1 receptor type

Gs

24

beta 2 receptor type

Gs

25

beta 3 receptor type

Gs

26

M1: 1. receptor type 2. effector enzyme & second messenger 3. location 4. effects

1. Gq 2. Stimulate PLC-->increase IP3 & DAG--> Increase Ca++ DAG remains bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particularly calcium channels in the smooth endoplasmic reticulum (ER). This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.[3] In addition, calcium and DAG together work to activate protein kinase C, which goes on to phosphorylate other molecules, leading to altered cellular activity. 3. Neurons 4. CNS effects

27

Receptors that act via Gi

alpha 2, M2

28

Effect of tyrosine hydroxylase

converts Tyrosine-->DOPA RATE LIMITING STEP in formation of Dopamine ADRENERGIC TRANSMISSION

29

NN receptor 1. location 2. type

1. ANS ganglia & Adrenal Medulla 2. Na/K channel

30

alpha 2 1. receptor type 2. effector enzyme & second messenger 3. location 4. effects

1. Gi 2. Inhibit adenylyl cyclase-->decrease cAMP 3. presynaptic neurons 4. reduces release of norepinephrine-->bradycardia & hypotension