Anti-fungals Flashcards Preview

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Flashcards in Anti-fungals Deck (38)
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31

MoA for caspofungin?

inhibit cell wall synthesis by inhibiting synthesis of ß1,3-d-glucan

32

Indications for caspofungin?

- invasive aspergillosis (3rd line rx)
- candida resistant to azoles or azole-allergic patients

33

ADR for caspofungin?

gi upset flushing (due to histamine release)fever, rash, n/vphlebitis,hepatits

34

nucleic acid synthesis inhibitors used as a anti-fungal therapy?

5-flucytosine*

35

MoA of 5-flucytosine?

inhibit DNA/RNA biosynthesis via conversion to 5-FU by cytosine deaminase

36

5-flucytosine is often used in combination with..?

amphotericin b

37

Indications of 5-flucytosine?

systemic fungal infections (cryptococcus meningitis)

38

ADR of 5-flucytosine

bone marrow suppression