Flashcards in Anti-fungals Deck (38)
MoA for caspofungin?
inhibit cell wall synthesis by inhibiting synthesis of ß1,3-d-glucan
Indications for caspofungin?
- invasive aspergillosis (3rd line rx)
- candida resistant to azoles or azole-allergic patients
ADR for caspofungin?
gi upset flushing (due to histamine release)fever, rash, n/vphlebitis,hepatits
nucleic acid synthesis inhibitors used as a anti-fungal therapy?
MoA of 5-flucytosine?
inhibit DNA/RNA biosynthesis via conversion to 5-FU by cytosine deaminase
5-flucytosine is often used in combination with..?
Indications of 5-flucytosine?
systemic fungal infections (cryptococcus meningitis)