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Flashcards in anti malarials Deck (14):
1

MOA & ADE of Artesunate

food vacuole makes toxic free radicals; GI

2

MOA & ADE of artemether/lumefantrine

food vacuole makes toxic free radicals; GI

3

MOA & ADE of chloroquine

inhibits heme breakdown causing toxic metabolites; GI, rash, headache, auditory/retinal dysfxn, neuropathy

4

how does resistance form against chloroquine

pumps/vacuoles

5

in what situation in chloroquine contraindicated

G6PD deficiency

6

MOA of Doxycycline

blocks 30S ribosomal subunit

7

MOA & ADE of Mefloquine

inhibits heme breakdown causing toxic metabolites; GI, rash, CV conduction, neurologic dysfxn

8

MOA & ADE of Primaquine

redox metabolites oxidize cell machinery (kills liver vivax/ovale schizonts!!!!!); Gi distress, methemoglobinemia, G6PD

9

MOA & ADE of quinine

binds dsDNA to prevent replication and transcription; cincohonism, G6PD, backwater fever

10

MOA & ADE of Pyrimethamine

sulfonamide blocks dihydropterate synthase/PABA (same as MTX… stops folate synth); glossitis, GI, rash, hemolysis, renal/hepato, protein binding. FOLIC ACID DEFICIENCY w/ high dose

11

MOA of Sulfadoxine

sulfonamide blocks dihydropterate synthase/PABA (same as MTX… stops folate synth); glossitis, GI, rash, hemolysis, renal/hepato, protein binding

12

what is the only drug that works in the liver

primaquine

13

what does primaquine kill in the liver

schizont

14

where do blood schizontacides work

in RBC