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Flashcards in Infections in IC host Deck (43):
1

who gets more infections kids or adults

kids

2

Immunocompromised pts are characterized by having

more infections, increased severity of those infections, diminished response to usually effective therapy, & patterns of infections are different

3

what do you call an infection by an organism that normally does not cause dz but does so when IC

opportunistic infections

4

what are 3 agents of opportunistic infections

Pneumocystis jirovecii, Cryptococcus neoformans, Fungal infections (other than thrush and tinea)

5

what is the basis of primary immunodeficiency

genetic defects

6

what are 3 ways to get a secondary immunodeficiency

1. acquired (HIV/AIDS)
2. anatomic and physiologic abnormalities (congenital asplenia/splenectomy, pumonary cyst, splenectomy)
3. Iatrogenic (urinary catheter, chemo)

7

infectious symptoms begin in first days-weeks of life

primary immunodeficiency

8

infection is often suppressed rather than eradicated by appropriate therapy

primary immunodeficiency

9

growth and development are commonly delayed

primary immunodeficiency

10

on a cellular level what is going on in primary immunodeficiency

-innate immunity: prob with phagocytes and compliment
-b lymphocytes: dysfxn in Ig prod & fxn
-t lymphocytes: can impact b cell fxn

11

absence of neutrophils

kostmann's congenital neutropenia (primary immunodeficiency)

12

neutrophil level fluctuates up and down

cyclic neutropenia

13

what bug can infect w/ neutrophil abnormalities

Aspergillus, candida, bacteria

14

C1-C4 deficiency

AI disorders

15

C5-C9 deficiency

neisseria spp. infection

16

properidin deficiency

neisseria spp. infection

17

how do you treat complement deficiency

immunizations and antibiotics if needed

18

defective BTK (bruton tyrosine kinase)

x-linked agammaglobulinemia

19

2-20 y/o w/ recurrent infections

CVID

20

what is the MC immunodeficiency

IgA deficiency

21

what do you not want to do in IgA deficiency

IgG replacement!!!!!!!!!!

22

No Tcells w/ effects on Bcell fxn

SCID

23

how do you tx SCID

stem cell transplant

24

congenital thymic hypoplasia, heart dz, hypoparathyroidism, neonatal hypocalcemia

Digeorge syndrome

25

neonatal hypocalcemia

Digeorge syndrome

26

what is a major late complication of digeorge syndrome

AI disorder late in life

27

thrombocytopenia, severe eczema

wiscott-aldridge syndrome

28

high risk for lymphoma

wiscott aldridge

29

how do you treat wiscott aldridge

stem cell transplant

30

what infections do you see with lymphocytic disorders

pneumocystis pneumonia; fungal infections; protozoal infections; disseminated viral infections; bacterial infection, malignancy

31

oral live attenuated vaccine in kid w/ SCID

polio

32

gets infection w/ catalase positive bacteria and fungi

phagocyte deficiency

33

gets neisseria infections

complement deficiency (C5-9)

34

gets infected w/ organisms w/ polysaccharide capsules

Ab deficiency (b cell)

35

gets opportunistic infections fungi and viruses

cellular and combined immunodeficiencies

36

kid comes in with recurrent URI

normal

37

what are you at risk for with either splenectomy or sickle cell dz

sepsis w/ encapsulated bacteria (ESP. S pneumonia!!!!!!!! ; and H flu)

38

Digeorge syndrome

Neonatal hypocalcemia !!!!!!!!

39

3 complications associated w/ pregnancy

UTI, HepE, H1N1 flu

40

what would you see clinically w/ chemo induced immunodeficiency

bacterial/candidal infection; aspergillosis, pneumocystic pneumonia, disseminated varicella

41

what are you worried about with transplant

risk of neutropenia plus profound lymphocytic dysfxn

42

partial albanism

chidiak hagashi

43

pseudomonas infection

leukemia