Antibacterial MOAs Flashcards Preview

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Flashcards in Antibacterial MOAs Deck (8):
1

Inhibit synthesis of bacterial cell walls

Penicillins, Cephalosporins, Vancomycin, Bacitracin
Cycloserine, azole antifungals (clotrimazole, fluconazole, itraconazole)

2

Alters cell membrane permiability

Detergents - Polymyxin B*
Polyene antifungal agents (amphotericin B, nystatin)

3

Inhibition of bacterial protein synthesis by 50S subunit

Chloramphenicol, macrolides (Erythromycin, azithromycin, clarithromycin, telithromycin), clindamycin, quinupristin/dalfopristin, linezolid

4

Inhibition of protein synthesis by 30S subunit

Aminoglycosides (streptomycin, tobramycin, gentamycin, amikacin), Tetracyclines (tetracycline, minocycline, doxycycline)

5

Inhibit DNA gyrase (topoisomerase)

Fluoroquinolones (ciprofloxacin, Levofloxacin)

6

Inhibit mRNA synthesis via DNA dependent RNA polymerase

Rifampin

7

Metabolic analogs - block folate synthesis

Trimethoprim, Sulfonamides

8

Metabolic analogs - Inhibit synthesis of mycolic acids

Isoniazid