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Flashcards in Corticosteroids (PE4) Deck (10):
1

Hydrocortisone

Short-medium acting glucocorticoid
Has mineralocorticoid activity
T1/2: 80-118 mins
Uses: adrenocortical insufficiency, anti-inflammatory and immunosuppressive, relief of inflammation, ulcerative colitis

2

Prednisone

Short-Medium acting glucocorticoid
Is a pro-drug, hepatic metabolism to active prednisolone
Slight mineralocorticoid activity - not good for patients with hypertension, CHF, salt retention
T1/2: 60 mins
Uses: Allergic states, autoimmune disorders, dermatologic conditions, edematous states, endocrine disorders, GI disorders, hemotologic disorders, MS, Neoplastic disease, optholmic disease, Respiratory disease, Rheumatic disorders, tuberculous meningitis

3

Methylprednisolone

Short-medium acting glucocorticoid

4

Triamcinolone

Intermediate acting glucocorticoid
Hepatic metabolism
NO mineralocorticoid activity
T1/2: >200 mins
Uses: Intralesional, nasal inhalation for allergic rhinitis, ocular inflammatory conditions, bronchial asthma, oral lesions, ulcerative lesions, adrenocortical insufficiency, derm diseases, endocrine disorders, GI disease, nephrotic syndrome, rheumatic disorders, allergic states, systemic lupus erythematosus

5

Dexmethasone

Long acting glucocorticoid
Hepatic metabolism
NO mineralocorticoid activity
T1/2: >300 mins
Uses: primarily as anti-inflammatory or immunosuppressant, conjunctivitis, inflammation of external ear canal due to otitis externa

6

Metyrapone

Glucocorticoid synthesis inhibitor and antagonist

7

Ketoconazole

Glucocorticoid synthesis inhibitor and antagonist

8

Fludrocortisone

Mineralocorticoids agonist
Hepatic metabolism
Mineralocorticoid with moderate glucocorticoid activity
T1/2: >35 mins
Uses: adrenocortical insufficiency in Addison's disease, salt-losing adrenogenital syndrome

9

Spironolactone

Glucocorticoid AND mineralocorticoid antagonist
Competitive inhibitor of aldosterone for sites in distal renal tubules, increase sodium chloride and water secretion but CONSERVES potassium and hydrogen ions
Hepatic metabolism
Mineralocorticoid activity
T1/2 >10 mins
*can cause tumors BBwarning
Uses: Edema due to excessive aldosterone activity, HTN, CHF, primary hyperaldosteronism, hypokalemia, cirrhosis of liver w/ edema/ascites

10

Cosyntropin

Glucocorticoid, mineralocorticoid, androgen, progesterone, and estrogen agonist
Stimulates adrenal cortex to secrete glucocorticoids, androgenic substances, and aldosterone (same as 25 U of ACTH)
Cortisol peak 60 mins post injection
Uses: diagnostic for differentiation of primary adrenal from secondary adrenocortical insufficiency