Glutamateric NMDA Receptor Flashcards Preview

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Flashcards in Glutamateric NMDA Receptor Deck (8):
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Receptor Type

Ligand-gated ionotropic receptor/non-selective cation channel

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Superfamily

Glutamate receptors
*Found ONLY in the CNS of vertebrates

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Structure

Tetramer of homologous subunits, 3 TM. Contains at least 7 genes

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Agonist and Co-agonist

Requires the binding of glutamate (agonist) and co-agonist (glycine) at the same time for activation. Interacts with AMPA receptor.
**Also Voltage dependent! Requires the depolarization of the cell to remove Mg blockage from the channel = activation

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Antagonist

AP5 and Memantine

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Function

Non-specific cation channel. Sense and mediate repetitive and excitatory synaptic activity, functions as a molecular coincidence detector for presynaptic glutamate release and postsynaptic Vm depolarization in a neuron. Plays critical role in synaptic plasticity (mechanism of learning and memory). Induces excitotoxicity as over-activated (causing excessive Ca influx that can lead to dysregulation, damage or neuron death).

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Phosphorylation

Increases its activity (excessive Ca influx is toxic).

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Unique Properties

Highly permeable to Ca
Voltage dependent - need depolarization to remove Mg blockade = activation
Needs binding of agonist and co-agonist