Flashcards in Glutamateric NMDA Receptor Deck (8):
Ligand-gated ionotropic receptor/non-selective cation channel
*Found ONLY in the CNS of vertebrates
Tetramer of homologous subunits, 3 TM. Contains at least 7 genes
Agonist and Co-agonist
Requires the binding of glutamate (agonist) and co-agonist (glycine) at the same time for activation. Interacts with AMPA receptor.
**Also Voltage dependent! Requires the depolarization of the cell to remove Mg blockage from the channel = activation
AP5 and Memantine
Non-specific cation channel. Sense and mediate repetitive and excitatory synaptic activity, functions as a molecular coincidence detector for presynaptic glutamate release and postsynaptic Vm depolarization in a neuron. Plays critical role in synaptic plasticity (mechanism of learning and memory). Induces excitotoxicity as over-activated (causing excessive Ca influx that can lead to dysregulation, damage or neuron death).
Increases its activity (excessive Ca influx is toxic).