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Flashcards in Cytokines Deck (21):
1

IL-1 alpha/beta

Macrophages, epithelial cells
*Induces fever, pro-inflammatory

2

IL-2

T cells (naive, Th0, Th1)
*Growth factor

3

IL-4

Th2 cells, mast cells
*Promote Th2 differentiation, B cell activation, B cell switch to IgE

4

IL-5

Th2, Mast cells
*promotes eosinophilia

5

IL-6

Th2 cells, macrophages, endothelial cells
*promote T and B cell growth, acute phase protein production, induces fever

6

IL-7

Stromal cells
*Promotes development of B and T cell progenitors

7

IL-8

Macrophages, endothelial/epithelial cells
*chemotactic factor for neutrophils and other granulocytes

8

IL-10

Monocytes, T cells, certain B cell subsets
*suppress macrophages and CTL, B cell growth factor

9

IL-12

Macrophages, dendritic cells
*Promotes Th1 differentiation, activates NK cells

10

IL-13

Th2 cells
*Promotes T/B cell growth, acute phase protein production, induces fever, inhibits macrophages

11

IL-17

Th17 T cells
*Increases neutrophil production, pro-inflammatory

12

IL-21

Th2 cells
*Proliferation of B, T, and NK cells

13

IL-22

NK cells, Th17 cells
*induces acute phase proteins, pro-inflammatory

14

IL-23

Dendritic cells, monocytes/macrophages
*Promotes development/proliferation of Th17 cells

15

TNF-alpha

Macrophage, NK cells, T cells
*promotes inflammation

16

Lymphotoxin-alpha

T and B cells
*induces apoptosis of targets

17

BAFF (Blys)

B cells
*Induces B cell proliferation, maturation, and survival

18

TGF-Beta1

Monocytes, T-cells, certain B cell subsets
*inhibits cell growth, anti-inflammatory, promotes IgA switch

19

IFN-alpha

all nucleated cells
*anti-viral, increases HLA Class I expression

20

IFN-beta

Fibroblasts
*anti-viral, increases HLA Class I expression

21

IFN-gamma

T cells, NK cells
*increases macrophage activation, HLA I and II expression