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Flashcards in T Helper Cell Differentiation Deck (21):
1

Th0 cells secrete?

IL-2, IL-4, IFN-gamma

2

Th1 cells differentiate from?

IL-12 and IFN-gamma

3

Th1 cells produce?

IL-2 and IFN-gamma

4

Th2 cells differentiate from?

IL-4 and IL-10

5

Th2 cells produce?

IL-4, IL-5, IL-10, IL-13

6

Th17 cells differentiate from?

IL-1B, IL-6, IL-21

7

Th17 cells produce?

IL-17, IL-21, IL-22

8

Tregs produce?

TGF-B, IL-4, IL-10

9

Produces IL-2, IL-4, IFN-gamma

Th0

10

Produces IL-2, IFN-gamma?

Th1 cells

11

Produces IL-4, IL-5, IL-10, IL-13?

Th2 cells

12

Produces IL-17, IL-21, IL-22?

Th17 cells

13

Produces TGF-B, IL-4, IL-10?

T-reg cells

14

Produced by IL-12 and IFN-gamma?

Th1 cells

15

Produced by IL-4 and IL-10?

Th2 cells

16

Produced by IL-1B, IL-6, and IL-21?

Th17 cells

17

Tregs have what markers on their cell surface?

CD4
CD25
Fox P3

18

Th1 cells function to?

"Type 1 immune response" (cell mediated immunity)
- Activate NK Cells
- Activate CTL cells
- Activate macrophages to increase phagocytosis
-Upregulate Th1 and activate other T-cells to become Th1
- B cells to undergo isotype switch to IgG3
- Downregulates Th2 response
-Activated against intracellular pathogens

19

Th2 cells function to?

"Type 2 immune responses" (humoral immunity)
- influence B cell isotype switch to IgG1, IgG2, IgG4, IgA or IgE
- promote activation of other T-cells to Th2
- Downregulate Th1
-Recruits eosinophils and basophils
- influence plasma cells v.s. Memory B differentiation
- Activated against extracellular antigens

20

Th17 cells function to?

- Involved in autoimmune diseases (RA, MS, psorasis, gut inflammation)
- Anti-fungal
- Increases production of neutrophils

21

T-reg cells function to?

- Regulates the immune response
- Downregulates host response to foreign antigens
- Prevents Th0 cells from responding to self antigens