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Flashcards in Neurotoxins Deck (3):

Tetrodoxin (TTX) / saxitoxin

From pufferfishes and algae,
*Bind to and block sites near the surface of Na channels


Batrachotoxin, aconitine, veratridine, and scorpion venom

Block Na channels by binding to their receptors OR by holding the voltage sensor (S4 segment of alpha1 subunit) at extracellular position
*Some neurotoxins also block Ca or K channels (w-conotoxins from snail and charybdotoxin from scorpions)


Neurotoxin effects

rapid paralysis, seizure, and death