Antibiotic Resistance Flashcards Preview

Disease and Defense Mine > Antibiotic Resistance > Flashcards

Flashcards in Antibiotic Resistance Deck (10):
1

Amp

-beta lactamase
-bla, TEM1, SHV1
-narrow spectrum: peni, amp

2

ESBL

-beta lactamase
-constitutive
-plasmid location
-E. coli, Klebsiella
-tx: carbapenem

3

AmpC

-beta lactamase
-inducible or constitutive
-chromosome location
-broad spectrum: penicillins (peni, amp), cephalosporins
-enterobacter, pseudomonas
-tx: carbapenem

4

KPC and NDM1

-carbapenemase
-broad spectrum: penicillins (peni, amp), cephalosporins, cerbapenems)
-klebsiella, E. coli

5

D Test

-positive D test confirms ERM inducible resistance
-current resistance to erythromycin
-possible resistance to clindamycin

6

ERM

-can occur in MSSA, MRSA
-confer resistance to macrolides (ACE)

7

Penicillin Binding Protein

-normally cross links cell wall
-change in PBP can confer resistance to all beta lactamases
-vanco still works
-change in d-ala to d-lac causes mecA to change PBP

8

VanA

-confers vanco resistance
-common in enterococcus

9

gyrA

-confers resistance to fluoroquinolones

10

TEM-1

-confers resistance to amoxacillin
-common in E. coli