Unit 4 Dermatology Flashcards Preview

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Flashcards in Unit 4 Dermatology Deck (59):
1

stasis dermatitis

-location: lower leg
-etiology: lower extremity edema

2

seborrheic dermatitis

-location: scalp
-etiology: malassezia furfur

3

atopic dermatitis

-location: flexor surfaces
-etiology: filaggrin
-associated with asthma and allergic rhinits

4

psoriasis

-location: extensor surfaces, may include arthritis
-may be associated with inc. risk of cardiovascular disease

5

irritant dermatitis

-etiology: common irritants

6

allergic contact dermatitis

-etiology: common allergens
-delayed hypersensitivity reaction type 4
-dx confirmed with patch testing

7

ABCDEs

A-asymmetry
B-border irregularity
C-color variation
D-diameter >6mm
E-evolution

8

keratoacanthoma

-subtype of squamous cell cancer

9

Langerhans Cells

skin cell critical to antigen processing and presentation to lymphocytes in epidermis

10

fibroblast

skin cell responsible for producing collagen

11

pruritis

-itch
-specialzed skin receptors: meissners corpuscles
-many triggers
-caused by nerve endings

12

darker skin color is due to:

differences in packaging and distribution of melanin

13

pacinian corpusles

-responsible for sensation of fine touch
-onion structure
-located in dermis only
-involved in pressure and vibration
-on genitals

14

meissners corpusles

-pine cone structure
-involved in fine touch
-dermal epidermal junction
-skin receptor
-on finger tips

15

eccrine glands

-odorless, watery sweat
-VITAL to thermal regulation
-present on lips, palms, soles, forehead
-acquired disorder: miliaria- blocked sweat ducts
-congenital: anhidrotic ectodermal dysplasia- mutation in EDA gene, poor temp regulation
-watery sweat

16

apocine glands

-primarily located in axilla
-outgrowths of the upper bulge of PEG
-not functional until puberty
-ex. breast feeding
-sticky sweat

17

sebaceous glands

-exemplify holocrine gland secretion
-lubricate thick, terminal hairs
-cause acne

18

leukocytoclastic vascultitis

immune complex mediated

19

Bowen's Disease

-squamous cell carcinoma
-linked to HPV infection

20

melassezia furfur

-associated with: tinea versicolor and seborrheic dermatitis

21

hemidesmosome

-attach dermis to epidermis
-in basement membrane zone

22

desomsomes

- cell adhesion between keratinocytes in stratum spinosum

23

Layers of Epidermis

surface- stratified squamous
-stratum corneum (filagrin connects this layer to other layers)
-stratum lucidum- on hands and feet only
-stratum granulosum- fillagrin cross links keratin filaments and is important in barrier functinon of skin
-stratum spinosum- keratinocytes
-stratum basalis- melanocytes and stem cells (skin color), desmosomes here
-1 melanocyte: 10 keratinocytes
-1 melanocyte can provide color to ~30 keratinocytes
-californians like girls (in) string bikinis

24

Dermis

-papillary
-reticular
-ground structures (assist with perfusion)
-collagen
-elastin
-blood vessels and nerves present
-also blood, nerves, adnexal structures

25

Fitzpatrick Skin Types

I. Never tans, always burns, freckles
II. Tans with difficulty, usually burns, freckles
III. Average tanning, sometimes burns, freckles
IV. Easily tans, rarely burns
V. Very easy to tan, very rarely burns
VI. Never burns

26

Melanin Types

-eumelanin- black to brown pigment
-pheomelanin- yellow to red-brown pigment

27

Skin Pigmentation Differences

Light Skin: melanosomes smaller and distributed in clusters above the nucleus in the keratinocyte
Dark Skin: melanosomes larger and distributed individually
throughout the cytoplasm of the keratinocyte

28

Flat Morphologies

-macule (<1 cm)
-patch

29

Raised Smooth Morphology

-papule (<1cm)
-plaque
-cyst
-nodule (1-2cm)

30

Fluid Filled Morphology

-vessicle (1 cm)
-pustule (pus)

31

eschar

crust

32

Tzanck Prep

test for herpes

33

Solar Elastosis

-acquired elastic disorder
-indicates tissue from older person in sun exposed site

34

Pseudoxanthoma Elasticum

-congenital elastic disorder
-caused by mutation in MDR gene
-"plucked chicken skin"

35

acquired disease of ground structure

-cosmetic filler agent

36

Ehlers Danlos Syndrome

-congenital disorder of collagen

37

scurvy

-acquired disorder of collagen

38

disorders of capillary loops

-psoriasis
-verruca

39

vasculitis

-inflamed blood vessels
-type 3 immune reaction

40

adnexal structures in dermis

-hair follicle
-eccrine gland- sweat
-apocrine
-apoeccrine
-sebaceous- oil

41

Hair Cycles

-anagen- growing (3 yrs)
-catagen- involution (3 weeks)
-telogen- resting hair (3 months)

42

Anagen Effluvium

-loss of growing hair

43

telgen effluvium

-hairs go into resting cycle

44

acquired disorders of sweating

-heat shock
-"antipersperant"

45

apoecrine gland

-hybrid sweat gland
-10x as much sweat as eccrine gland

46

actinic keratosis

-most common precancer in US
-turns in SQUAMOUS and basal cell cancers

47

benign vascular skin tumors

-cherry angioma
-hemangioma

48

benign vascular malformation (endothelial cells)

-port wine stain

49

benign sebaceous gland tumors

-sebaceous hyperplasia
-nevus sebaceous

50

beingn fibroblast tumors

-dermatofibroma
-keloid scars

51

benign keratinocyte tumor

-seborrheic keratosis (barnacles of life)

52

benign tumor of melanocyte

nevus

53

peptides involved in innate immunity of skin

-alpha defensins
-beta defensins
-cathelicidin
-psoriasin
-RNase7

54

veruca

-means wart
-caused by HPV

55

KOH test

-detects fungus

56

aspergillis

lung infection fungus

57

powder + grease =

-protective pastes

58

grease + liquid =

-ointments
-creams
-lotions

59

powder + liquid =

-drying pastes
-gels
-shake suspensions