Practice Quiz Unit 2 Flashcards Preview

Disease and Defense Mine > Practice Quiz Unit 2 > Flashcards

Flashcards in Practice Quiz Unit 2 Deck (32):
1

Synthesized in liver. Activated at site of activity. NOT created on as need basis.

Bradykinin

2

Involved in scar formation. Chronic.

Fibroblast

3

Anaphylotoxins. Lead to histamine release from mast cells.

C3a & C5a

4

Chemical mediator of inflammation. Released by nerve endings. Causes pain.

Substance P

5

Chemical mediator. Stored in pre-formed vesicle. Ready for immediate release. Associated with IgE antibody.

Histamine

6

Associated with fever. Associated with acute phase reaction.

Tumor Necrosis Factor, TNF

7

Arachadonic acid + cyclooxygenase =

Prostaglandin

8

Involved in: platelet activation, vasoconstriction, bronchospasm, chemotaxis

Platelet Activating Factor

9

Activates kallikrein. Associated with C5.

Coagulation Factor XII

10

Functions include: opsonization, formation of membrane attack complex, chemotaxis, anaphylaxis

Complement Cascade

11

Arachadonic acid + 5-lipoxygenase =

Leukotriene

12

Which molecule is frequently downregulated to allow for loosening up of cell-cell interactions, facilitating cancer cell detachment from the primary tumor?

E Cadherin

13

Transcriptional repressors of E Cadherin that are often upregulated in tumor cells.

SNAIL, TWIST, ZEB 1/2

14

Factor involved in degrading and remodeling the ECM, allowing for tumor cell invasion.

Matrix Metalloproteinases (MMPs)

15

Process where normal cells undergo apoptosis when they lose adhesion to the ECM. Many metastatic cells have lost this property.

Anoikis

16

Substance capable of causing cancer in living tissue. Type of mutagen.

Carcinogen

17

Name of substance that changes genetic material.

Mutagen

18

Clinical outcome of cancer is generally prognosticated by:

Tumor Stage

19

Alkylating agents preferentially target:

DNA, causing cross links and inhibition of synthesis

20

Drug that produces most of the undesirable side effects of cortisol. Most potent corticosteroid.

Dexamethasone

21

Loss of morphological characteristics of adult cells, or loss of differentiation.

Anaplasia

22

Disordered growth, loss of normal cell maturation, may lead to neoplasia.

Dysplasia.

23

Increase in cell number.

Hyperplasia

24

Change in cell type.

Metaplasia.

25

Virchow's Triad

1. abnormal blood flow
2. hypercoagulability
3. endothelial injury

26

Condition where formation of one blood clot causes systemic lack of clotting factors, and may lead to bleeding.

Disseminated Intravascular Coagulation (DIC)

27

Inhibition of COX2 to by NSAIDS like celecoxib leads to what type of blood flow in kidneys?

NSIAD inhibition of COX 2 leads to decreased renal blood flow.

28

Inhibition of thomboxane-TXA2 synthesis results in _______ risk for blood clotting.

Decreased

29

Inhibition of prostaglandin synthesis results in _________ uterine contractions.

Decreased

30

Inhibition of prostacyclin synthesis results in _________ risk for clotting.

Increased

31

Inhibition of ___________ synthesis results in decreased risk for blood clotting.

Thomboxane-TXA2

32

Inhibition of __________ synthesis results in increased risk for clotting.

Prostacyclin