Flashcards in Practice Quiz Unit 2 Deck (32):
Synthesized in liver. Activated at site of activity. NOT created on as need basis.
Involved in scar formation. Chronic.
Anaphylotoxins. Lead to histamine release from mast cells.
C3a & C5a
Chemical mediator of inflammation. Released by nerve endings. Causes pain.
Chemical mediator. Stored in pre-formed vesicle. Ready for immediate release. Associated with IgE antibody.
Associated with fever. Associated with acute phase reaction.
Tumor Necrosis Factor, TNF
Arachadonic acid + cyclooxygenase =
Involved in: platelet activation, vasoconstriction, bronchospasm, chemotaxis
Platelet Activating Factor
Activates kallikrein. Associated with C5.
Coagulation Factor XII
Functions include: opsonization, formation of membrane attack complex, chemotaxis, anaphylaxis
Arachadonic acid + 5-lipoxygenase =
Which molecule is frequently downregulated to allow for loosening up of cell-cell interactions, facilitating cancer cell detachment from the primary tumor?
Transcriptional repressors of E Cadherin that are often upregulated in tumor cells.
SNAIL, TWIST, ZEB 1/2
Factor involved in degrading and remodeling the ECM, allowing for tumor cell invasion.
Matrix Metalloproteinases (MMPs)
Process where normal cells undergo apoptosis when they lose adhesion to the ECM. Many metastatic cells have lost this property.
Substance capable of causing cancer in living tissue. Type of mutagen.
Name of substance that changes genetic material.
Clinical outcome of cancer is generally prognosticated by:
Alkylating agents preferentially target:
DNA, causing cross links and inhibition of synthesis
Drug that produces most of the undesirable side effects of cortisol. Most potent corticosteroid.
Loss of morphological characteristics of adult cells, or loss of differentiation.
Disordered growth, loss of normal cell maturation, may lead to neoplasia.
Increase in cell number.
Change in cell type.
1. abnormal blood flow
3. endothelial injury
Condition where formation of one blood clot causes systemic lack of clotting factors, and may lead to bleeding.
Disseminated Intravascular Coagulation (DIC)
Inhibition of COX2 to by NSAIDS like celecoxib leads to what type of blood flow in kidneys?
NSIAD inhibition of COX 2 leads to decreased renal blood flow.
Inhibition of thomboxane-TXA2 synthesis results in _______ risk for blood clotting.
Inhibition of prostaglandin synthesis results in _________ uterine contractions.
Inhibition of prostacyclin synthesis results in _________ risk for clotting.
Inhibition of ___________ synthesis results in decreased risk for blood clotting.