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Flashcards in ANtibodies and markers Deck (29)
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1

Anti-scl 70 antibody

Systemic Sclerosis

2

Anti-RNA polymerase III

Scleroderma renal crisis

3

NEED TO KNOW....what are the earliest Pthological changes seen in SSc

changes in endothelial cell function with increased apoptosis, upregulation of MHC class II and upregulation of ICAM-1 (intracellular adhesion molecules)

4

Anti-topoisomerase 1 (Anti- SCL 70)

BAD PROGNOSIS for SSc pts with lung disease

5

Remember, the most basic problem in scleroderma is that fibroblasts are activated and they lay down riduiculous amounts of collagen.

ok

6

Anti-DNA Ab

Sensitive for Lupus, used for screenings

- correlates with presence of renal disease

7

Anti-dsDNA

SPECIFIC for lupus... nails the diagnosis

8

Anti-Histone Ab

DRUG INDUCED LUPUS

9

Anti-Sm (smith)

LUPUS disease activity

10

HLA-DR2

Lupus

11

HLA-DR4

RA

12

HLA-B27

Spondyloarthropathy

13

Anti-cardiolipin antibody / Anti-lupus anticoagulant

lupus anti-phospholipid syndrome

14

ANticardiolipin leads to false

syphilis test

15

lupus anti-coagulant leads to

False elevated PTT

16

Lupus anticoagulant is named for its affect on PTT

It looks like you are prone to bleeding b/c of the PTT results. In reality, you are in a hypercoaguable state. May lead to DVT, hepatic Thrombosis, AND PLACENTAL THROMBOSIS....this causes the recurrent pregnancy loss

Long story short...anti-coag is a terrible name and you have to take an anticoagulant for your entire life.

17

TREX1

Important SLE pathogenesis

18

Anti- SS-A/Ro and Ant- SSB-/La

Sjogren's syndrome.....and Neonatal lupus

19

U1 Ribonucleoprotein

Mixed connective tissue DZZZZZ

20

Nearly all pts with undifferentiated connective tissue disease have

Raynauds and some unexplained synovitis

21

Synthetase and PML/Scl antibodies predict differentiation into what?

myositis overlap syndrome

22

Dilated capillaries in the nailfolds suggest

conective tissue disease

23

Anti-CCP

Rheumatoid arthritis (sensitive and specific)

24

PDGFR

Scleroderma

25

MMP

Scleroderma

26

Low serum complement

SLE, vasculitis

27

Sjogren cancer risk

Lymphoma, unilateral parotid swelling

28

c-ANCA

Wegeners

29

p-ANCA

Micro, poly, churg strauss, IBD