Flashcards in Vasculitis Pathophys Deck (48)
Polyarteritis Nodosum is a vasculitis of what size vessels
Medium mostly. Spares the Large elastic arteries like the aorta and also spares small vessels such as arterioles, venules, capillaries.
Does PAN cause Glomerulonephritis
Nope...SO no RBC casts in the urine
What disease predisposes to PAN in 30% of pts
What is the cousing of Polyarteritis Nodosum that affects very small vessels?
Polyarteritis tends to affect which sex
What is one symptom that should automatically make you think PAN
Peripheral neuropathy....thes patients may have involvement of the peroneal, tibial, ulnar, or radial nerve). Sensory dysthesias may dominate the clinical picture. WRIST DROP OR FOOT DROP
What are some other clinical signs and symptoms of Polyarteritis Nodosum
Kidney involvement, GI involvement, cardiac,
What ORgan system does PAN spare
Diagnosis of PAN
What will you see on PAN biopsy
Treatment plan for PAN?
Treat the underlying Hep B if it exists
Also treat with steroids and cytotoxic agents.
THey will probably die
What makes Microscopic polyangitis different from PAN
It affects very small vessels
It DOES cause Glomerulonephritis
It DOES cause lung involvement
ANd it is way more common than PAN
Granulmoas associated with PAN or Microscopic Poly
Trick question, NEither
Is microscopic polyangiitis associated with anti-nbeutrophil antibodies>?
Granulomatosis with polyangiitis definition?
Focal necrotizing vasculitis of medium and small vessels
What is teh prototypical Pauci Immune vasculitis?
Granulomatosis with Polyangiitis
Classic triad of P w/G
ELK (ENT, Lung, Kidney)
Other Pw/G signs and symptoms
Systemic like fever, wt loss, malaise
Describe the ELK signs
E: Nasal ulcerations, mucosal ulcerations, saddle nose
L: Pulmonary infiltrates and nodules
Allergic Granulomatosis with polyangitis is also called
Henoch Schonlein Purpura
HSP genearlly follows
exposure to a specific drug
HSP is more common in?
IgA is high in what disease?
Purpura, arthritis, abdominal pain, Glomerulonephritis (PAAG)
Skin involvement in HSP is usually where?
Lower extremities and buttocks
PAAG tetrad of HSP broken down
Purpura, Arthritis, Abdominal Pain, Glomerulonephritis
GOOD! usually just goes away
Buerger's disease usually affects what first
vascular supply to the lower limbs