Vasculitis Pathophys Flashcards Preview

Musculoskeletal > Vasculitis Pathophys > Flashcards

Flashcards in Vasculitis Pathophys Deck (48)
Loading flashcards...
1

Polyarteritis Nodosum is a vasculitis of what size vessels

Medium mostly. Spares the Large elastic arteries like the aorta and also spares small vessels such as arterioles, venules, capillaries.

2

Does PAN cause Glomerulonephritis

Nope...SO no RBC casts in the urine

3

What disease predisposes to PAN in 30% of pts

Hepatitis B

4

What is the cousing of Polyarteritis Nodosum that affects very small vessels?

Microscopic polyangittis

5

Polyarteritis tends to affect which sex

Male (2:1)

6

What is one symptom that should automatically make you think PAN

Peripheral neuropathy....thes patients may have involvement of the peroneal, tibial, ulnar, or radial nerve). Sensory dysthesias may dominate the clinical picture. WRIST DROP OR FOOT DROP

7

What are some other clinical signs and symptoms of Polyarteritis Nodosum

Kidney involvement, GI involvement, cardiac,

8

What ORgan system does PAN spare

THE LUNGS!!!!

9

Diagnosis of PAN

biopsy

10

What will you see on PAN biopsy

Fibrinoid Necrosis!

11

Treatment plan for PAN?

Treat the underlying Hep B if it exists
Also treat with steroids and cytotoxic agents.
THey will probably die

12

What makes Microscopic polyangitis different from PAN

It affects very small vessels
It DOES cause Glomerulonephritis
It DOES cause lung involvement
ANd it is way more common than PAN

13

Granulmoas associated with PAN or Microscopic Poly

Trick question, NEither

14

Is microscopic polyangiitis associated with anti-nbeutrophil antibodies>?

Yeah... P-ANCA

15

Granulomatosis with polyangiitis definition?

Focal necrotizing vasculitis of medium and small vessels

16

What is teh prototypical Pauci Immune vasculitis?

Granulomatosis with Polyangiitis

17

Classic triad of P w/G

ELK (ENT, Lung, Kidney)

18

Other Pw/G signs and symptoms

Systemic like fever, wt loss, malaise

19

Describe the ELK signs

E: Nasal ulcerations, mucosal ulcerations, saddle nose

L: Pulmonary infiltrates and nodules

K: Glomerulonephritis

20

SADDLE NOSE=

WEGNERS

21

Allergic Granulomatosis with polyangitis is also called

Henoch Schonlein Purpura

22

HSP genearlly follows

exposure to a specific drug

23

HSP is more common in?

Kids

24

IgA is high in what disease?

HSP!!!

25

HSP tetrad

Purpura, arthritis, abdominal pain, Glomerulonephritis (PAAG)

26

Skin involvement in HSP is usually where?

Lower extremities and buttocks

27

PAAG tetrad of HSP broken down

Purpura, Arthritis, Abdominal Pain, Glomerulonephritis

28

HSP prognosis

GOOD! usually just goes away

29

Buerger's disease usually affects what first

vascular supply to the lower limbs

30

Signs and symptoms of Buerger's

Bilateral pain and ischemia in the lower limbs, though upper extremities may be affected first in the cold