Flashcards in Lupus and Sjogrens Deck (50)
Systemic Lupus Erythematosus definition?
Multi-system inflammatory disorder
Autoantibodies to numerous self antigens
only involves the skin though these Discoid lesions CAN be seen in SLE
Drug induced Lupus
Less severe than SLE
Self-limiting once the offending drug is removed.
Newborns of mothers with SLE
-skin rash, heart block (permanant), thrombocytopenia
What are the three problems of neonatal lupus
skin rash, heart block(which is permanent), and thrombocytopenia
Female to male ration in lupus
Peak incidence of lupus?
Blacks 3-4 times more likely
Lupus is called the disease of a thousand faces. WHy
Can present in tons of different ways
Common general symptoms of lupus
Malaise, fever, fatigue
Cutaneous manifestations of lupus
Malar rash, alopecia
Malar rash, along with other symptoms, get worse upon exposure to what?
Discoid lesions heal with.....
Arthralgias, arthritis, myalgias, myositis
Arthralgia and myalgia are just joint and muscle pain. The -itis' are inflammation
Ulnar deviation that can be corrected occurs in what dz?
Ulnar deviation that cannot be corrected (fixed ulnar deviation) occurs in
DrP Key: what kind of genetic deficiency confers the highest risk of dz
DrP Key: This mutation is important in lupus and it points to impaired regulation of endogenous nucleic acids
DrP Key: The production and affect of ...... has emerged as central to Lupus Pathogenesis
Type 1 Interferon
Renal Disorders in lupus are correlated with the presence of what?
If renal dz is active the anti-dsDNA is high
What is the most common renal structure affected
Glomerulus....they all CAN be affected.
--- RBC casts in Urine
--- And proteinuria.......this is a glomerulonephritis, dawg
Psychiatric abnormalities in Lupus?
Depression, psychosis, cognitive abnormalities
What do you first do if a pt presents with neurological disease like a seizure and they have lupus?
EXCLUDE OTHER CAUSES like a brain tumor
Anemia, thrombocytopenia, leukopenia
Most common pulmonary maifestation
pleuritis with pleural effusion
Most common cardiac manifestation
What can happen on the valves
Libman sacks endocarditis
Obstetrical complications of Lupus?
Small babies, and receurrent fetal loss