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Flashcards in Lupus and Sjogrens Deck (50)
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1

Systemic Lupus Erythematosus definition?

Multi-system inflammatory disorder
Autoantibodies to numerous self antigens

2

Discoid lupus

only involves the skin though these Discoid lesions CAN be seen in SLE

3

Drug induced Lupus

Less severe than SLE
Self-limiting once the offending drug is removed.

4

Neonatal lupus

Newborns of mothers with SLE
-skin rash, heart block (permanant), thrombocytopenia

5

What are the three problems of neonatal lupus

skin rash, heart block(which is permanent), and thrombocytopenia

6

Female to male ration in lupus

13:1

7

Peak incidence of lupus?

Childbearing years

8

Racial discrimination

Blacks 3-4 times more likely

9

Lupus is called the disease of a thousand faces. WHy

Can present in tons of different ways

10

Common general symptoms of lupus

Malaise, fever, fatigue

11

Cutaneous manifestations of lupus

Malar rash, alopecia

12

Malar rash, along with other symptoms, get worse upon exposure to what?

SUN

13

Discoid lesions heal with.....

scars

14

Musculoskeletal complaints

Arthralgias, arthritis, myalgias, myositis

Arthralgia and myalgia are just joint and muscle pain. The -itis' are inflammation

15

Ulnar deviation that can be corrected occurs in what dz?

Lupus

16

Ulnar deviation that cannot be corrected (fixed ulnar deviation) occurs in

Rheumatoid Arthritis

17

DrP Key: what kind of genetic deficiency confers the highest risk of dz

Complement Deficiency

18

DrP Key: This mutation is important in lupus and it points to impaired regulation of endogenous nucleic acids

TREX1

19

DrP Key: The production and affect of ...... has emerged as central to Lupus Pathogenesis

Type 1 Interferon

20

Renal Disorders in lupus are correlated with the presence of what?

anti-dsDNA antibodies

If renal dz is active the anti-dsDNA is high

21

What is the most common renal structure affected

Glomerulus....they all CAN be affected.
--- RBC casts in Urine
--- And proteinuria.......this is a glomerulonephritis, dawg

22

Psychiatric abnormalities in Lupus?

Depression, psychosis, cognitive abnormalities

23

Neurological dz

STROKE, myelitis,

24

What do you first do if a pt presents with neurological disease like a seizure and they have lupus?

EXCLUDE OTHER CAUSES like a brain tumor

25

Heme manifestation

Anemia, thrombocytopenia, leukopenia

26

Most common pulmonary maifestation

pleuritis with pleural effusion

27

Most common cardiac manifestation

pericarditis

28

What can happen on the valves

Libman sacks endocarditis

29

Obstetrical complications of Lupus?

Small babies, and receurrent fetal loss

30

Anticardiolipin/ antiphospholipid antibody syndrome can cause what?

blood clots, can lead to multiple miscarriages.