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Flashcards in Joint Diseases Handorff Deck (26)
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1

Osteoarthritis most commonly affects which joints

Back, knee, hand, hip...joints that bear a lot of stress

2

Symptoms of osteoarthritis

painful joints, pain after joint has been used, discomfort during significant weather changes, swelling in a joint, stiffness in a joint, bony lumps in the joint

3

What is the bony growth in joints that appears during osteoarthritis

This is the body's attempt to repair the joint

4

Risk factors of Osteoarthritis

Being a woman, over 45, previous injury, obesity, diseases that cause malformation of bone structure

5

Rheumatoid Arthritis is a disease stemming from a disorder of what?

The immune system

6

Rheumatoid arthritis is most common in who>

Women. Between the ages of 20 and 50

7

RA tends to affect which joints

small joints of the hands and feet, loss of range of motion, loss of muscular strength in the muscles attached to the affected joints
also:
-low grade fever
- fatigue which can be severe during flare ups
- stiffness or aching
- malaise
-

8

Too many notecards....probably

ok

9

What is the cause of RA

Unknown really. CD4 cells aggregate and secrete cytokines to attract B cells and macrophages. These B cells and macrophages form the inflammatory response

Many patients have IgM antibodies to the Fc receptors on IgG. These immune complexes form extra-articular manifestations and can be measured as rheumatoid factor

10

20% of pts with rheumatoid arthritis get a

Rheumatoid nodule

11

What does a rheumatoid nodule look like?

consists of an acellular center of eosinophillic material surrounded by palisaded histiocytes and other cells, maybe with a rim of granulation tissue

12

Where do Rheumatoid nodules occur?

Generally on
-Extensor surfaces
-Aortic valve, pericardium, lung parenchyma

13

What the fuck is a pannus

Basically you get this acute and chronic synovitis during RA which leads to proliferation of vascular connective tissue in the synovium.
This later fills with Polys, T cells, and plasma cells
Pannus means a membrane of granulation tissue. It can proliferate over time and contribute to joint destruction. It erodes cartilage and bone.

14

Gouts main cause

high levels of uric acid

15

Joint may swell, become warm to the touch and red in appearance. Pt may develop a fever and a skin lump that is white and chalky in appearance.

ok

16

Joint pain in gout often affects

Great toe, knee, and ankle
Rare that only one joint is affected

17

Higher risk for gout in

Men, postmenopausal women, alcohol drinkers

18

Urate chrystals form when the concentration of uric acid in the body reaches

7 mg/dl at normal body temperature. These chrystals form faster at lower temps that why they usually form in the toes and fingers (furthest from the heart, where the temp is lowest)

19

yellow= urate= parallel

ok

20

calcium = yellow= perpendicular

ok

21

Pseudogout

calcium phosphate deposition

22

Infectious arthritis

bacterial infection in joint

23

How do these organisms arrive?

blood

24

Infectious arthritis usually infects what joints?

Large ones

25

Giant cell tumor of Tendon sheath

Basically you look for a bunch of multinucleated giant cells and a background of histiocytes. DONT CONFUSE WITH TB

26

Pigmented Villonodular synovitis

Localized destructive lesion within a single joint (usually the knee), proliferation of synovium, hemosiderin pigmentation, destroys the joint