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Flashcards in Vasculitis Nicholls Deck (40)
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1

What are some signs and symptoms of vasculitis in general?

Fever, myalgia, arthralgia, malaise

- Also palpable Purpura (these are just erythematous tender skin nodules), focal skin necrosis and ulceration
- Livedo reticularis (this is a purplish discoloration of the skin due to dilation of the blood vessels,

- Urticaria

2

What is the key to diagnosis of vasculitis?

Distribution of organ involvement and histopathologic features

3

What are the common causes of infectious vasculitis?

Fungal (aspergillus)
Bacterial (Pseudomonas)
Viral (cytomegalovirus)

4

In temporal giant cell arteritis, what are the Giant cells doing?

THey attack the internal elastic Lamina and destroy it.
- You get intimal thickening that can lead to stenosis

5

Clinical manifestations of TGCA

- headache in 75% of pts
- swollen tender artery
- scalp tenderness
- visual disturbances
- jaw claudication

6

Peripheral neuropathy most common with

polyarteritis nodosa

7

Nodular pulmonary infiltrates most associated with

Granulomatosis with polyangiitis

8

Infectious vasculitis may cause

mycotic aneurysm

9

Inflammation in TGCA is

Segmental, Transmural, granulomatous

10

TGCA affects arteris of what size?

Medium

11

Why is it important that TGCA is segmental?

Biopsies may be false negatives

12

Why is is important that TGCA is transmural?

More easily narrows the lumen.....whereas atherosclerosis takes 50 years to narrow your coronary, TGCA takes just a few years.

13

Describe the inflammation of Takayasu Arteritis

Segmental, Transmural, loosely grnulomatous, and .....Necrotizing

14

Takayasu Arteritis can involve the aorta and cause

dissection--> rupture --> hemopericardium-- > DEAD

Basically Cardiac Tamponade (bunch of blood in the pericardium)

15

Polyarteritis Nodosa inflammation is:

Segmental, transmural, NODULAR

16

What is the most characteristic feature of polyarteritis nodosa

Fibrinoid necrosis

17

Acute phase of PN

- neutrophils, intimal thickening, cell proliferation and degeneration, luminal stenosis

-Also may see: thrombosis, occlusion, rupture...all of which occur at BRANCHPOINTS of the artery

18

Later phases of PN

Chronic inflammation, fibroblasts, scarring

19

Unlike temporal arteritis, aneurysms are .... in PN

fairly common

20

Lesions are at...........phases at the same time in PN

DIFFERENT

21

Livedo reticularis can be a feature of

PN....basically just looks like a net like rash...its dilated blood vessels so that makes sense

22

Kawasaki disease features

Endothelial necrosis + transmural inflammation with neutrophils, lymphocytes, wall necrosis,and aneurysms

23

Aneurysms are most characteristic of which vasculitis?

Kaawasaki

24

What tests do we use for Kawasaki disease?

There is no blood test. It is a clinical diagnosis based on history and physical

25

Kawasaki's disease is most common at what age?

1

26

Describe Granulomatosis with polyangiitis

Necrotizing granulomatous vasculitis of both ARTERIES AND VEINS in the UPPER AND LOWER RESP TRACT ANS KIDNEYS

27

Histology of granulomatosis with polyangiitis looks like

Geographic areas of necrosis with basophillic debris, BLUED

28

ANCA-PR3

Granulomatosis with Poly

29

Signs and symptoms of granulomatosis with Poly

Mucosal ulcers, necrotizing lesions, Nasal cartillage destruction

30

Most common site of involvement on presentation with GP

URT