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Flashcards in Spondyloarthropathy Deck (17)
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1

Common features of all the spondyloarthropathies?

-Not a damn one of them involves rheumatoid factor
- All are associated with HLA B27
- Axial onvolvement with sacroilitis and spondylitis is common
- Large joint asymmettric oligoarthritis
- TNF alpha plays a crucial role

2

What are two other common features

Enthesitis- inflammation at the sites where tendons and ligaments attach

Dactylitis- Sausage digits

3

HLA B27 is an MHC class I molecule that binds antigenic peptides and presents them.

true

4

HLA-B27 is most common in who7

Pts with ankylosing spondylittis

5

Frequency of B27 in pts with reactive arthritis

75%

6

What does HLA-B27 confer

Increased disease severity and susceptibility

7

Pts with HLA B27 are more likely to develop

axial arthropathy`

8

Pathogenesis of ankylosing spondylitis

HLA-B27 plays a major role along with some other non MHC genes:
ARTS
IL1A
IL23

Cytokine dysregulation with OVEREXPRESSION of TNF-alpha

9

What is the primary target for th eabnormal immune response in ankylosing spondylitis?

Cartilage

10

AS features inflammation of the spinal joints leading to bony fusion.
Inflammation of the peripheral joints
Extra-articular disease

all true

11

AS tends to affect who?

Younger people (adolescence to age 35)
Males moreso than females

12

What is ankylosing spondylitis associated with in the eyes?

Anterior Uveitis

13

PEripheral joint involvement is present in what percentage of AS pts

1/3
Involves hips shoulders knees and ankles
Oligoarticular, often asymetric

14

Cardiac complications of AS

aortic regurg, heart block

15

Pulmonary AS

apical lung fibrosis, thoracic cage restriction

16

Renal AS

secondary amyloidosis

17

Neuro AS

spinal fractures C5-C6...no more cards for now