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Step 1 2019 First Aid Flashcards > Antibodies, Mabs, markers, hard Rx > Flashcards

Antibodies, Mabs, markers, hard Rx Flashcards

(97 cards)

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1
Q

HLA A3

A

Hemochromatosis HA3mochromatosis.

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2
Q

HLA B8

A

Addison disease, myasthenia gravis, Graves disease Don’t Be late(8), Dr. Addison, or else you’ll send my patient to the grave

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3
Q

B27

A

Psoriatic arthritis, Ankylosing spondylitis, IBD-associated arthritis, Reactive arthritis

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4
Q

HLA C

A

Psoriasis

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5
Q

DQ2/DQ8

A

Celiac disease

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6
Q

DR2

A

Multiple sclerosis, hay fever, SLE, Goodpasture syndrome

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7
Q

DR3

A

DM type 1, SLE, Graves disease, Hashimoto thyroiditis, Addison disease 2-3, S-L-E.

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8
Q

DR4

A

Rheumatoid arthritis, DM type 1, Addison disease There are 4 walls in 1 “rheum” (room).

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9
Q

DR5

A

Hashimoto thyroiditis Hashimoto is an odd Dr (DR3, DR5)

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10
Q

Anti-ACh receptor - which disease

A

Myasthenia gravis

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11
Q

Anti-presynaptic voltage-gated calcium channel

A

Lambert-Eaton myasthenic syndrome

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12
Q

Antiβ2 glycoprotein I

A

Antiphospholipid syndrome

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13
Q

Anticardiolipin

A

SLE, antiphospholipid syndrome

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14
Q

Anti-dsDNA, anti-Smith

A

SLE

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15
Q

Anti-histone

A

Drug-induced lupus

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16
Q

diseaseAnti-U1 RNP (ribonucleoprotein)

A

Mixed CT disease

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17
Q

anti-CCP

A

RA

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18
Q

Anti-Ro/ SSA, anti-La/SSB

A

Sjogren syndrome

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19
Q

anti-DNA topoisomerase I

A

Scleroderma (diffuse)

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20
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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21
Q

Antisynthetase (eg, anti-Jo-1), anti-SRP, anti- helicase (anti-Mi-2)

A

Polymyositis, dermatomyositis

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22
Q

Antimitochondrial

A

1° biliary cholangitis

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23
Q

Anti-smooth muscle

A

Autoimmune hepatitis type I

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24
Q

MPO-ANCA/p-ANCA

A
  • Microscopic polyangiitis,
  • eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome)
  • ulcerative colitis
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25
PR3-ANCA/c-ANCA
Granulomatosis with polyangiitis (Wegener
26
Anti-phospholipase A 2 receptor
1° membranous nephropathy
27
Anti-hemidesmosome
Bullous pemphigoid
28
Anti-desmoglein (anti-desmosome)
Pemphigus vulgaris
29
Antimicrosomal, antithyroglobulin, antithyroid peroxidase
Hashimoto thyroiditis
30
Anti-TSH receptor
Graves disease
31
IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptide
Celiac disease
32
Anti-glutamic acid decarboxylase
Type 1 diabetes mellitus
33
islet cell cytoplasmic antibodies
Type I diabetes mellitus
34
Antiparietal cell, anti-intrinsic factor
Pernicious anemia
35
Anti-glomerular basement membrane
Good pasture syndrome
36
Drug vs CD52 - what clinical use?
Alemtuzumab, CLL & MS
37
Vs VEGF - Rx/Dx used for?
Bevacizumab; Colorectal cancer, renal cell carcinoma, non-small cell lung cancer neovascular agerelated macular degeneration, proliferative diabetic retinopathy, and macular edema
38
vs CD20
Rituximab B-cell non-Hodgkin lymphoma, CLL, rheumatoid arthritis, ITP, MS
39
vs HER2
Trastuzumab breast cancer, gastric cancer
40
vs Soluble TNF alpha - Rx? Dz? Using this could lead to reactivation of?
Adalimumab, infliximab IBD, rheumatoid arthritis, ankylosing spondylitis, psoriasis Reactivation of Myc TB
41
decoy TNF-α receptor
Etanercept
42
vs Complement protein C5 - rx? dz?
Eculizumab Paroxysmal nocturnal hemoglobinuria
43
α4-integrin - rx? dz?
Natalizumab; MS, Crohn disease
44
IL-12, IL-23 - rx? dz?
Ustekinumab Psoriasis, psoriatic arthritis
45
Platelet glycoproteins IIb/IIIa - rx? dz?
Abiciximab Antiplatelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention
46
vs RANKL
Denosumab Osteoporosis; inhibits osteoclast maturation (mimics osteoprotegerin)
47
vs IgE
Omalizumab Refractory allergic asthma
48
vs RSV F protein
Palivizumab RSV prophylaxis for high-risk infants
49
Ab vs PD-1 or PD-L1
Inhibited by antibodies against PD-1 (eg, pembrolizumab, nivolumab) or PD-L1 (eg, atezolizumab, durvalumab, avelumab).
50
anti CTLA4 antibody
Ipilimumab
51
Alkaline phosphatase
Metastases to bone or liver, Paget disease of bone, seminoma (placental ALP).
52
α-fetoprotein
Hepatocellular carcinoma, Endodermal sinus (yolk sac) tumor, Mixed germ cell tumor, Ataxia-telangiectasia, Neural tube defects. (HE-MAN is the alpha male!)
53
hCG - assoc with?
Hydatidiform moles and Choriocarcinomas (Gestational trophoblastic disease), pure embryonal carcinoma ( can be inc in seminoma/yolk sac)
54
CA 15-3/CA 27-29
Breast cancer.
55
Calcitonin
Medullary thyroid carcinoma (alone and in MEN2A, MEN2B).
56
CEA
Major associations: colorectal and pancreatic cancers. Minor associations: gastric, breast, and medullary thyroid carcinomas.
57
Chromogranin
Neuroendocrine tumors.
58
LDH
Testicular germ cell tumors, ovarian dysgerminoma, other cancers
59
Neuron-specific enolase
Neuroendocrine tumors (eg, small cell lung cancer, carcinoid tumor, neuroblastoma
60
Chromogranin and synaptophysin - target and tumor?
Neuroendocrine cells Small cell carcinoma of the lung, carcinoid tumor
61
Cytokeratin - target/tumor?
Epithelial cells Epithelial tumors (eg, squamous cell carcinoma)
62
DesMin - target/tumor?
``` Muscle Muscle tumors (eg, rhabdomyosarcoma) ```
63
GFAP - target/tumor?
NeuroGlia (eg, astrocytes, Schwann cells, oligodendrocytes) Astrocytoma, Glioblastoma
64
Neurofilament - target? tumors?
``` Neurons Neuronal tumors (eg, neuroblastoma ```
65
PSA
Prostatic epithelium Prostate cancer
66
S-100 - target? tumors?
Neural crest cells Melanoma, schwannoma, Langerhans cell histiocytosis
67
Vimentin - target? tumors?
``` Mesenchymal tissue (eg, fibroblasts, endothelial cells, macrophages) Mesenchymal tumors (eg, sarcoma), but also many other tumors (eg, endometrial carcinoma, renal cell carcinoma, meningioma) ```
68
p450 inducers
* Modafinil * Chronic alcohol use * St. John’s wort * Phenytoin * Phenobarbital * Nevirapine * Rifampin * Griseofulvin * Carbamazepine
69
p450 substrates
Warfarin Anti-epileptics Theophylline OCPs
70
p450 inhibitors
* Valproate * Amiodarone * Cimetidine /Omeprazole * Ketoconazole * Fluconazole * Chloramphenicol * Erythromycin/clarithromycin * Sulfonamides * Ciprofloxacin * Metronidazole * Ritonavir * Acute alcohol abuse * Grapefruit juice
71
PSK9 (-)'rs - use?
Alirocumab, evolocumab (-)'n of LDL-R degratdation --\> Inc removal of LDL
72
IL2 recombinant - use?
Aldesleukin RCC, metastatic melanoma
73
TPO receptor agonists - use?
eltrombopag, romiplostim ITP
74
reverses dabigatran bleeding if that's not available, then use?
idarucizumab tranexamic acid
75
Cetuximab, panitumumab - mech and use?
Monoclonal antibodies against EGFR. Stage IV colorectal cancer (wild-type KRAS), head and neck cancer.
76
Dabrafenib, vemurafenib mech, use?
Small molecule inhibitors of BRAF oncogene ⊕ melanoma. Metastatic melanoma.
77
β-interferon, glatiramer, natalizumab used for what?
MS
78
Acute flares of MS - use?
IV steroids
79
Ruxolitinib - use?
janus kinase inhibitor (JAK inhibitor) with selectivity for subtypes JAK1 and JAK2 myelofibrosis, PCV when not responsive to hydroxyurea
80
Anagrelide - what dz?
essential thrombocytosis
81
Daclizumab - was used for ______ disease, but now largely out of use bc of __________ (side effect)
MS ;encephalitis
82
Basiliximab
vs IL 2 R binds to alpha chain - CD25
83
Degarelix - MoA, Dz?
GnRH antagonist prostate cancer
84
Goserelin - rx? dz?
GnRH analogue breast, prostate cancer
85
competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney.
Sulfinpyrazone - used for gout
86
Imiquimod used for what dz?
genital warts, superficial basal cell carcinoma, and actinic keratosis
87
Lumacaftor Ivacaftor - mech, dz
lumacaftor (corrects misfolded proteins and improves their transport to cell surface) ivacaftor (opens Cl– channels Ž improved chloride transport).
88
VDRL test - detects Ab that reacts with beef \_\_\_\_\_\_\_\_\_ False POS VDRL =?
VDRL detects nonspecific antibody that reacts with beef cardiolipin. False-Positive results on VDRL with: Pregnancy Viral infection (eg, EBV, hepatitis) Drugs Rheumatic fever Lupus and leprosy
89
nitazoxanide - used for?
Cryptosporidium in immunocompetent hosts
90
CMV uses what receptor?
Integrins (heparan sulfate)
91
EBV receptor
CD21
92
HIV uses what receptors?
CD4, CXCR4, CCR5
93
Parvo virus B19 receptor
P antigen on RBCs
94
Rabies receptor
Nicotinic AchR
95
Rhinovirus receptor
ICAM-1
96
Mirabegron - works on what receptor? use?
B3 - urinary urge incontinence or overactive bladder
97

Step 1 2019 First Aid Flashcards (63 decks)

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