MuscSkCT - FA Pharm p474 - 476

Question 1

Anti inflammatory agents blocks an enzyme that converts ———-to arachidonic acid

Answer 1

phospho - lipids

Question 2

which drug does not participate in the corrosive effect of G.I Lining.

Answer 2

celecoxib (COX2 only)

Question 3

what is the MOA of Aspirin?

Answer 3

Irreversible blockers of Cox 1 & 2

Question 4

List 5 reversible blockers of COX 1 & 2

Answer 4

diclofenac, ibuprofen, indomethacin, ketorolac Naproxen

Question 5

what drug blocks 5 Lipoxygenase

Answer 5

ZIleuton

Question 6

list two drugs that block leukotrienes receptors

Answer 6

montelukast zafrilukast

Question 7

List the chemotaxic agents

Answer 7

LTB4, IL8, C5a, bacteria cell wall

Question 8

what leukotrienes increase bronchial tone

Answer 8

LTC4, D4 & E4

Question 9

what drug is an analog PGI2

Answer 9

Epoprostenol

Question 10

what are the functions of prostacyclins

Answer 10

Inhibit platelet aggregation & decrease vascular tone & promote vasodilation

Question 11

Prostaglandin E1 function and what drug is associated with it

Answer 11

dec vascular tone (ALoprostadil)

Question 12

what drug increase uterine tone

Answer 12

Dinoprostone (PGE2) Carboprost (PGF2alpha)

Question 13

two function of thromboxane

Answer 13

inc platelet aggregation inc vascular tone

Question 14

what is the function of alprostadil?

Answer 14

dec vascular tone

Question 15

Acetaminophen MOA?

Answer 15

reversible inhibit cycloxygenase mostly in CNS

Question 16

what are the clinical use of Acetaminophen

Answer 16

antipyretic, analgesic & NOT anti-inflammatory

Question 17

what drug can be substituted in children to prevent Reye Syndrome

Answer 17

Acetaminophen

Question 18

SE of Aceetaminophen

Answer 18

hepatic necrosis

Question 19

describe the process of acetaminophen induced hepatic necrosis

Answer 19

NAPQI depletes glutathione and forms toxic tissues byproduct in the liver

Question 20

what is an antidote for Acetaminophen overdose

Answer 20

N-Acteylcysteine (regenerating glutathione)

Question 21

what other disease is N-acetylcsteine used to treat and describes its MOA

Answer 21

C.F and weakens mucous plugs

Question 22

by what process does Aspirin used to inhibit CoX

Answer 22

Covalent Acetylation

Question 23

inc bleeding time and no effect on PT & PTT is seen in what drug

Answer 23

Aspirin (Effects last until new platelets are produced)

Clopidogrel

Question 24

what is the function of aspirin at low dose ?

Answer 24

dec platelet aggregation

Question 25

what is the function of aspirin at medium dose (300- 2400mg/day)

Answer 25

Antipyretic & analgesic

Question 26

what is the function of aspirin at high dose (2400-4000mg/day)

Answer 26

Anti- Inflammatory

Question 27

Tinnitus is caused by what anti-inflammatory medication

Answer 27

Aspirin

Question 28

what drug causes early respiratory alkalosis and late mixed metabolic acidosis-respiratory alkalosis

Answer 28

Aspirin

Question 29

If a child has Varicella zoster and Influenza B, and is given _______ (drug), it can lead to this ______ side effect

Answer 29

Aspirin, reye's

Question 30

by inhibiting COX2 only, then you do not affect what?

Answer 30

Gastric mucosa function (maintenance of this is helped by COX1)

Question 31

what drug increases the risk of thrombosis and could cause allergy in some patients

Answer 31

celecoxib (Sulfa Allergy)

Question 32

clinical use of celecoxib

Answer 32

osteoarthritis and Rheumatoid Arthritis

Question 33

what drug reversibly blocks prostaglandin synthesis

Answer 33

NSAIDs, acetominophen

Question 34

what drug closes PDA

Answer 34

(Indomethacin)

Question 35

what is the role of prostaglandin in the kidneys?

Answer 35

Vasodilator afferent arterioles

Question 36

What drug has a side effect of renal Ischemia

Answer 36

NSAIDS

Question 37

MOA of Leflunomide and what part of DNA pathway does it block?

Answer 37

Reversible inhibits dihydro-orotate dehydrogenase blocking pyrimidine synthesis

Question 38

which drug suppresses T-cell proliferation

Answer 38

Leflunomide

Question 39

4 SE of Leflunomide

Answer 39

Hepatotoxicity, Teratogenic, diarrhea and HTN

Question 40

clinical use of Leflunomide

Answer 40

RA, Psoartic arthritis

Question 41

what drug binds hydroxyapatite in bone

Answer 41

Bisphosphonate

Question 42

what drug inhibits osteoclastic activity

Answer 42

Bisphosphonate

Question 43

what medication should the patient be advised to take with water and remain upright for 30 minutes and why?

Answer 43

Bisphosphonates (causing esophagitis) NSAIDs Tetracyclins potassium chloride ferrous sulfate

Question 44

what drug causes osteonecrosis of the jaw and atypical stress fractures

Answer 44

Bisphosphonate

Question 45

List the bisphosphonates

Answer 45

Alendronate, Ibandronate, Risedronate, Zoledronate

Question 46

what drug causes transient hypercalcemia

Answer 46

teriparatide

Question 47

a recombinant parathyroid analog given subcutaneously daily

Answer 47

teriparatide (inc osteoblastic activity)

Question 48

list the drugs that inhibit xanthine oxidase

Answer 48

allopurinol, febuxostat

Question 49

A recombinant uricase that catalyze metabolism of uric acid to allantoin

Answer 49

Pegloticase - allatoin is more water soluble

Question 50

what drug inhibit reabsorption of uric acid in PCT

Answer 50

probenecid

Question 51

list of drugs to treat acute gout?

Answer 51

NSAIDS (indomethacin, naproxen), Steroids, Colchicine

Question 52

what drug impairs neutrophils chemotaxis and degranulation with a G.I side effect

Answer 52

Colchicine

Question 53

list the TNF alpha inhibitors use for gout

Answer 53

infliximab, adalimumab, certolizumab, golimumab

Question 54

what drug do you use to treat tumor Lysis Syndrome?

Answer 54

aggresive hydration, allopurinol, Rasburicase

Question 55

What is MOA of rasburicase

Answer 55

recombinant Uricase that catalyze metabolism of uric acid to Allantoin

Question 56

Bonus: what blood drug inhibit microtubule polymerization/ stabilizes microtubules and what disease do they treat and what fungi drug has the same MOA

Answer 56

vincristine (non-Hodgkin), Vinblastine (Hodgkin), - leukemia too, solid tumors paclitaxel - ovarian and breast carcinoma Griseofulvin (Antifungi)

Question 57

what is the MOA of Erlotinib whats the S.E??

Answer 57

EGFR tyrosine kinase Inhibitor used for non small cell lung carcinoma and S.E is rash and photosensitivity

Question 58

what drug is a mast cell degranulator (-)'r?

Answer 58

cromolyn

Question 59

what can be used to treat hemorrhagic cystitis from cyclophosphamide toxicity?

Answer 59

N-Acetyl cysteine

Question 60

what type of COX is found in platelet and G.I

Answer 60

cox 1

Question 61

If you are on ____ diuretic, avoid NSAIDs. Why?

Answer 61

Loops. Bc Loops (+) PGE release (VD aff art), and NSAIDS would block this effect.

Question 62

what loop diuretics should be used in a patient with sulfa allergies

Answer 62

Ethacrynic acid

Question 63

What anti inflammatory drug would be safe in a patient with renal issues, but would cause Steven Johnson?

Answer 63

sulindac

Question 64

what drug increase osteoblastic activity for osteoporosis

Answer 64

teriparatide

Question 65

What other drug can be used to prevent and treat osteoporosis

Answer 65

Raloxifene

Question 66

what is the clinical presentation of Lesch Nyhan syndrome?

Answer 66

HGPRT Hyperuricemia Gout Pissed off retardation dystonia

Question 67

what is MOA of terbinafine

Answer 67

inhibit squalene epoxidase

Question 68

Rx vs Sclerostin - used to inc osteoblastic activity

Answer 68

Romosuzumab