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Step 1 2019 First Aid Flashcards > Pharm Qs Conrad Fischer > Flashcards

Pharm Qs Conrad Fischer Flashcards

(63 cards)

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1
Q

Adapalene

A

acne - vit A topical 0.1% gel

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2
Q

Aliracumab, Evalocumab

A

PCSK9 (-)’r, used when can’t use statins, 2nd line drug for severe hyperlipidemia

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3
Q

Aflibercept

A

vs VEGF - for macular degeneration

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4
Q

Ranizumab

A

vs VEGF - for macular degeneration

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5
Q

Ranizumab is from the same class of drug as?

A

Bevacizumab

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6
Q

Rx for Paralytic Ileus? MOA?

A

Alvimopan - Mu receptor inhibitor in bowel.

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7
Q

Apremilast

A

PDE4 (-)’r used for plaque psoriasis, psoriatic arthritis

Inc cAMP = dec inflammation

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8
Q

Other Rx that inhibit the same enzyme as Apremilast?

A

Theophylline - (-) PDE

Dypiridymole, Cilostazole - (-) PDE in platelets, dec platelet aggregation, cause VD

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9
Q

Drug that (-) C diff toxin?

A

Bezlotoxumab

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10
Q

Drugs for CLL:

Which Rx is vs CD52, also used for what other disease

A

Alemtuzumab, Hairy Cell leukemia & MS

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11
Q

CLL Rx vs Bruton’s tyrosine kinase

A

Ibrutinib

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12
Q

CLL Rx vs Phosphatidyl inositol kinase

A

Idelasib, vs P110δ, the delta isoform of the enzyme phosphoinositide 3-kinase

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13
Q

CLL Rx vs CD20

A

Ocrelizumab - also in MS
Ofatumumab
Obinutuzumab

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14
Q

CLL rx vs BCL2

A

Venetoclax

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15
Q

Paratumumab - which disease, MOA, and used with which other Rx?

A

used in Multiple myeloma, anti CD 38 IgG

Used with Lenalidomide & Dexamethasone

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16
Q

Helps in COPD with drooling, and inc BD? MOA?

A

Glycopyrrolate, mACh-R (-)’r

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17
Q

Rx - Reversal of a direct thrombin inhibitor?

A

Idarucizumab - reverses Dabigatran

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18
Q

Heart Rx that is anti-anginal, inhibits Na funny channels? When is it used?

A

Ivabradin.
CHF - Used when EF <35%, and HR >70 when already on ACE< BB and mineralocorticoid (-)’r
Or in Angina when can’t use BB

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19
Q

SE of Ivabradin?

A

Luminous phenomena/visual brightness - bc same Na funny channels are in the eye
hypertension, bradycardia.

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20
Q

Ivacaftor/Lumacaftor ?

A

used to treat people with cystic fibrosis who have the F508del mutation in CFTR.

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21
Q

Rx vs IL-17? used in what disease? (3)

A 
Ixekizumab
Secukinumab
Brodalumab
used in plaque psoriasis, and psoriatic arthritis
used when MTX and TNF alpha Rx fail
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22
Q

Secukinumab is also used in what other disease? Instead of what drug?

A

Ankylosing spondylitis, used over Etanercept (TNF inhibitor)

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23
Q

Lesinurad

A

used in Gout - dec uric acid levels, bc (-) renal absorption of uric acid

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24
Q

Rx vs CD25 used in MS?

A

Daclizumab

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25
Rx that speeds up walking in MS?
Dalfampridine (4-Aminopyridine)
26
MS rx that will inhibit lymphocyte release?
Fingolimod (oral) - sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction.
27
Dimethyl fumarate
oral MS and psoriasis drug
28
Teriflunomide
oral MS drug, which is the active metabolite of leflunomide, | inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase.
29
2 rx used in idiopathic pulmonary fibrosis?
Nintdanib, Pirfenidone - tyrosine kinase inhibitor vs vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR).
30
Nivolumab
human IgG4 anti-PD-1 monoclonal antibody Used in Inoperable or metastatic melanoma following treatment of ipilimumab It is also used to treat metastatic squamous non-small cell lung cancer with progression with or after platinum-based drugs. (Cisplantin) 2nd line rx - renal cell carcinoma after anti-angiogenic treatment has failed. PD-1 is a protein on the surface of activated T cells. If another molecule, called programmed cell death 1 ligand 1 or programmed cell death 1 ligand 2 (PD-L1 or PD-L2), binds to PD-1, the T cell becomes inactive. This is one way that the body regulates the immune system, to avoid an overreaction.[7] Many cancer cells make PD-L1, which inhibits T cells from attacking the tumor. Nivolumab blocks PD-L1 from binding to PD-1, allowing the T cell to work.
31
Obeticholic acid
Primary biliary cholangitis - Farsenoid X receptor agonist - anti-inflammatory, anti-fibrotic
32
Rx vs IL-2? Used in which disease?
Aldesleukin, used in RCC and metastatic melanoma
33
Patiromer
will bind K in the bowel, releases Ca in exchange - used for hyperkalemia, but not for acute lowering of it. Allows use of ACE/ARBs when they might increase K+, dec progression of potential renal failure - keeps pt off dialysis
34
Pimavanserin
5HT(-)'r - used in Parkinson's, no issue with inc dopamine induced psychosis SE// Can prolong QT
35
Riociguat
primary pulmonary HTN - GC (+)'r = pulm art VD
36
Sacubitril
used in CHF - Nephrilysin (-)'r, added to ARB esp valsartan, Dec mortality, NOT added to ACE (-)'r
37
Selexipag
prostacyclin receptor agonist - primary pulmonary HTN, oral pulm art VD
38
Talimogene
used in Melanoma (when it can't be operated on - is injected directly into it - oncolytic virus HSV genetically modified)
39
Teduglutide
Used in Short Bowel syndrome, GLP analogue (glucagon like peptide 2 - GLP2)
40
Ustekinumab
(-) IL 12 & 23, used in psoriasis, psoriatic arthritis
41
Vedolizumab
alpha integrin (-)'r, will (-) lymphocytes in peyer's patches. used in drug resistant IBS
42
Velpatasvir
used in Hep C with Sofosbuvir with HIV or cirrhosis
43
Vorapaxar
used in Peripheral Art Disease, antiplatelet thrombin-R (-)'r
44
Imatinib
bcr-abl and c-kit tyrosine kinase inhibitor | used in CLL, CML , GI stromal tumors (c-kit)
45
Letrozole, Anastrozole
aromatase (-)'r, lowers level of estrogen used in breast cancer in post menopausal women
46
Tamoxifen
Blocks estrogen-R
47
Rituximab
vs CD20, used in B-cell non-Hodgkin lymphoma, CLL, rheumatoid arthritis, ITP
48
Anakinra
interleukin 1 (IL1) receptor antagonist. used in RA
49
Abatacept
Abatacept binds to CD80/CD86, (-) co stimulatory signal to activate T cells. used in RA ( In order for a T cell to be activated and produce an immune response, an antigen presenting cell must present two signals to the T cell. One of those signals is the major histocompatibility complex (MHC), combined with the antigen, and the other signal is the CD80 or CD86 molecule (also known as B7-1 and B7-2). Abatacept binds to the CD80 and CD86 molecule, and prevents the second signal. Without the second signal, the T cell can't be activated.)
50
Leflunomide
Used in RA instead of MTX, inhibits dihydroorotate | dehydrogenase (stops pyrimidine synthesis)
51
Pramipexole, Cabergoline, Ropinirole
dopamine agonist, used in Restless leg syndrome and Parkinson's
52
Epoprostenol
pulmonary HTN
53
Bosentan
pulmonary HTN, Competitively antagonizes ENdothelin-1 receptors pulmonary vascular resistance SE// Hepatotox, monitor LFTs
54
ATRA (all trans retinoic acid)
Acne, AML
55
Daptomycin, Linezolid
used in MRSA Daptomycin - Lipopeptide that disrupts cell membranes of gram ⊕ cocci by creating transmembrane channels. Linezolid - (-) prot synthesis @ ribosome 50S subunit
56
Eplerenone
CHF - major SE// INC K+ > gynecomastia
57
Montelukast
Asthma | SE//Churg Strauss
58
Prasozosin, Tamsulosin
BPH SE//Orthostatic HTN
59
Finasteride, Dutasteride
5 alpha reductase (-)'r, Testosterone --> DHT
60
Bethanochol
Activates bowel and bladder smooth muscle; resistant to AChE, no nicotinic activity.
61
Artesunate, Artemether
severe malaria
62
Foscarnet -
Viral DNA/RNA polymerase inhibitor and HIV reverse transcriptase inhibitor. Binds to pyrophosphate-binding site of enzyme. CMV retinitis
63
Antithymocyte globulin
Used in pancytopenia (aplastic anemia)

Step 1 2019 First Aid Flashcards (63 decks)

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