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Step 1 2019 First Aid Flashcards > Random Qs Rx > Flashcards

Random Qs Rx Flashcards

1
Q

Filgrastim - what is it?

A

G-CSF

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2
Q

Dexrazoxane - what is it?

A

Fe chelator, (-) Anthracycline (Doxorubicin) cardio tox (dilated cardiomyopathy)

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3
Q

Amifostine - used when?

A

Given with Cisplantin to dec nephrotox

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4
Q

Finasteride, Dutasteride - MOA, used for?

A

5 alpha reductase inhibitor, used in BPH

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5
Q

Tamsulosin, Silodosin - MOA

A

Alpha 1 - R (-)’r, used in BPH, urinary specific

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6
Q

Aldesleukin - what is it, used for?

A

IL-2, Melanoma & RCC

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7
Q

Alemtuzumab - MOA, which disease

A

Mab vs CD52, used in CLL;MS

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8
Q

Bevacizumab - MOA, which disease, SE?

A

(-) VEGF, Colorectal cancer, renal cell carcinoma, non-small cell lung cancer

SE// dec wound healing

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9
Q

Which Rx cause granulocytosis

A

Clozapine, Carbamazepine, Propylthiouracil, Methimazole, Colchicine, Ganciclovir

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10
Q

Rx that cause inc in LFTs

A

Statins, Ezetimibe, Amiodarone, Thyroid storm Cetuximab, Valproic acid, Bosentan

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11
Q

Rx that cause Hypothyroidism

A

Lithium, amiodarone, sulfonamides

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12
Q

Rx that cause hyperuricemia (Gout)

A

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine

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13
Q

Antivirals - What are -Avirs, -Ivirs, -Ovirs used for?

A

-Avirs = AIDS, -Ivirs = Influenza, -Ovirs = Herpes

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14
Q

Detemir, Glargine are?

A

long acting insulin

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15
Q

Sulfonyureas - list them, MOA?

A

-Ides
1st gen: Chlorpropamide, Tolbutamide
2nd gen: Glimepiride, Glipizide, Glyburide
Close K+ channel in Beta cell membrane –> cell depolarizes –> insulin release via Inc Ca2+ influx

“Ides of March” - Ceaser Killed the K+ channel

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16
Q

SGLT2 (-)’rs - List and MOA?

A

Canaglifozin, Dapagliflozin, Empagliflozin - block reabsorption of glucose of PCT.

Stops the Glucose Flow In - Gli-flo-zin

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17
Q

Which Antibiotics are lipid soluble so therefore not eliminated by the kidney?

A

Doxycyclin, Ceftriaxone, Cefperazone, Naficillin, Oxacillin

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18
Q

IFN alpha used for?

A

Hep B& C, CML, Hairy B cell leukemia, Kaposi sarcoma

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19
Q

IFN Beta used for?

A

Inc length of remission in MS

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20
Q

IFN gamma used for?

A

Chronic granulomatous disease

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21
Q

Repaglinide - MOA?

A

Used in T2DB, stimulates postprandial insulin release by binding to K+ channels on B cell membranes (diff site from sulfonylureas)

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22
Q

Rx used in Hodgkin’s

A

A - Adriamycin
B - Bleomycin
V - Vincristine
D - Dacarbazine, Doxorubicin

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23
Q

Peracetam - MOA?

A

-racetams (like Levetiracetam) - may modulate GABA and glutamate release, used for clonus
SE// Fatigue, drowsiness, headache, neuropsychiatric

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24
Q

Rasburicase - MOA? Use?

A

Recombinant uricase that catalyzes metabolism of uric acid to allantoin (which is 5-10x more soluble). Prevention and treatment of tumor lysis syndrome.

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25
Denosumab
(-) osteoclasts maturation, Ab vs RANK-L ; Osteoporosis
26
Leukovorin
used for Methrotrexate toxicity (save from myelosuppression)
27
N-Acetyl-Cysteine
vs Acetominophen Toxicity, Inc glutathione
28
Filgrastim
G-CSF
29
Sargagrastim
GM-CSF (stimulate granulocytes and monocytes)
30
MESNA
for hemorrhagic cystitis due to cyclophosphamide
31
List 5 SSRIs - SE// and Tox?
Sertraline, Fluoxetine, Paroxetine, Citalopram, Fluvoxamine SE//Bruxism, dec libido, weight LOSS, anxiety TOX// Serotonin syndrome
32
SSRIs are contraindicated with ?
MAOIs, Meperidine, TCAs
33
Rx that cause Pancreatitis?
Valproic acid, Didanosine & Stavudine (HIV rx), L-Asparaginase
34
Rx that cause Sulfa allergy
Carbonic anhydrase (-)'rs, Loops, Thiazides, Sulfonamides, Sulfonylureas, Celecoxib, Sumatriptan
35
Rx that can cause DB inspidus
Democlocycline , Li
36
Rx that cause Ototox/Nephrotox
Aminoglycosides, vancomycin, loop diuretics, cisplatin, amphotericin B
37
Disulfiram like reactions
1st-generation Sulfonylureas, Procarbazine, | certain Cephalosporins, Griseofulvin, Metronidazole
38
Rx that cause photosensitivty
``` Sulfonamides, Simepravir (HIV protease (-)'r ), Amiodarone, Tetracyclines, 5-FU, ```
39
Rx that act on Microtubules
``` Mebendazole (anti-helminthic) Griseofulvin (anti-fungal) Colchicine (anti-gout) Vincristine/Vinblastine Paclitaxel (used in breast/ovarian cancer) ```
40
SLE like reaction
Sulfa drugs, Hydralazine, Isoniazid, | Procainamide, Phenytoin, Etanercept, alpha methyldopa
41
Methotrexate - MOA? SE?
folic acid analog, (-) DHF reductase, will dec nucleotide precursors and WBC proliferation SE// myelosuppression, hepato Tox, interstitial lung disease
42
Busulfan - MOA? SE?
DNA cross linking protein - will be cytotoxic to myeloid (low dose) and WBC (high dose). Use for CML and w. cyclophosamide to prep for bone marrow transplant SE//GI issues, pancytopenia, hyperpigmentation
43
Rx that lead to SIADH
Carbamazepine, Cyclophosphamide, SSRIs
44
Fomepizole
(-) alcohol DH, antidote for methanol ethylene gycol
45
Hydroxyurea
(-)ribonucleotide reductase
46
Rifampin
(-) RNA polymerase
47
Actinomycin D
inhibits RNA polymerase in both prokaryotes and eukaryotes.
48
TNF alpha assoc Rx
Adalimumab, certolizumab, golimumab, infliximab are all soluble TNF alpha. Etanercept is a decoy TNF-α receptor and not a monoclonal antibody
49
Natalizumab - what is it, what diseases
α4-integrin, used in Crohn's MS
50
Chloramphenicol
50S inhibitors, used Rickettsia if doxycyclin not avail *(-) peptidyl transferase (-) elongation at A--> P
51
Tetracyclin
works at A site, 30S inhibitor, bacteriostatic
52
Rx that causes Restless Leg syndrome
Pramipexole
53
Rx used in Paroxysmal Nocturnal Hematuria
Eculizumab
54
Paclitaxel is? used in?
Breast, ovarian cancer. - will Hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down (anaphase cannot occur).
55
Alemtuzumab
vs CD52 - used in CLL
56
Riluzole - for?
ALS
57
Rx for Essential Tremor
Non sel BB, Primidone
58
Mycophenolate
inhibit inosine | monophosphate dehydrogenase - inhibit purine synthesis
59
Rx that (-) de novo purine synthesis
6- Mercaptopurine, Azt
60
(-) dihydro folate reductase
MTX, TMP, Pyramethamine
61
(-) viral entry into cells
Enfuvirtide
62
Sibutramine
appetite suppressant no longer used
63
Flutamide
competitive antagonist at the androgen receptor, a nuclear receptor that affects transcription
64
Fibrates
(+) PPAR alpha to induce HDL synthesis, Inc LPL (Inc TAG clearence)
65
Triamterene
(-) Na channels @ collecting tubule; K sparing diuretic

Step 1 2019 First Aid Flashcards (63 decks)

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