MuscSkCT - FA Patho Derm p465 - 473

Question 1

Name the pathology associated with this dermal morphology: honey crusts

Answer 1

Impetigo caused by GAS

Question 2

Name the pathology associated with this dermal morphology: transient smooth plaque/papule known as wheal

Answer 2

Urticaria

Question 3

Name the pathology associated with this dermal morphology: bulla

Answer 3

Bullous pemphigoid,

Question 4

Name the pathology associated with this dermal morphology: flaking off skin, scales

Answer 4

Psoriasis Eczema

Question 5

Hemidesmosomes connect ————— to ————? Which pathology is associated with it?

Answer 5

keratin in basal cells ; basement membrane. Bullous pemphigoid

Question 6

Which layer of the epidermis produces progenitor cells

Answer 6

Stratum Basale

Question 7

Which layer of the epidermis has diffuse layers of keratin?

Answer 7

Stratum Corneum

Question 8

Which layer of the epidermis has desmosomes? Which pathology is associated with them

Answer 8

Stratum spinosum. Auto immune destruction of desmosomes is observed in pemphigous vulgaris

Question 9

Which structure allows for communication in gaps junctions?

Answer 9

Connexons (channel proteins)

Question 10

Loss of these filaments with these abnormal proteins in this junction leads to metastasis?

Answer 10

Mutated E-cadherins without actin filaments in Zonula adherens (Adherens JXN)

Question 11

Which tumors is MG associated with

Answer 11

Thymoma

Question 12

Which type of hypersensitivity is Vitiligo associated with

Answer 12

Type IV

Question 13

Failure of NC to migrate to the skin and decreased number of melanocytes

Answer 13

Piebaldism

Question 14

normal migration of NC cells with decreased melanin granules

Answer 14

Albinism

Question 15

What two conditions can lead to acquired hyperpigmentation of the face in females?

Answer 15

1) Pregnancy 2) OCP usage

Question 16

Differentiate b/w Acantholysis and Acanthosis (pathologies associated with it)

Answer 16

Acanthosis- epidermal hyperplasia (nigricans in metabolic syndrome) Acantholyis- separation of epidermal cells (pemphigus vulgaris

Question 17

staphylococcal Exotoxin destroys keratinocyte attachments in — only vs. toxic epidermal necrolysis, which destroys —.

Answer 17

stratum granulosum epidermal-dermal junction

Question 18

T or F? HSV1 and HSV2 can cause herpetic whitlow?

Answer 18

T (finger) (dentist and wrestlers)

Question 19

Which infection involving upper dermis and superficial lymphatics, usually from S. pyogenes?

Answer 19

Erysipelas

Question 20

Which infection causes multiple crops of lesions in various stages from vesicles to crusts?

Answer 20

Varicella zoster virus

Question 21

Erythema multiforme is associated with which infections, paths and drugs?

Answer 21

Infection: Mycoplasma pneumoniae, HSV

drugs: sulfa drugs, β-lactams, phenytoin cancers autoimmune disease

Question 22

A small, rough, erythematous or brownish papules or plaques that inc the risk of squamous cell carcinoma is called what?

Answer 22

Actinic keratosis

Question 23

Hairy leukoplakia occurs in what kind of pt? What virus mediates it?

Answer 23

Occurs in HIV-positive patients, organ transplant recipients. EBV mediated

Question 24

What is a more severe form of Stevens-Johnson syndrome with > 30% of the body surface area involved ?

Answer 24

toxic epidermal necrolysis

Question 25

Obese Pt with gastric adenocarcinoma may present with what type of kind disorder?

Answer 25

Acanthosis nigricans (hyperplasia of spinosum)

Question 26

Wickham striae seen in Lichen Planus refers to what?

Answer 26

Mucosal involvement manifestations, (reticular white lines)

Question 27

Lichen Planus is associated with what virus?

Answer 27

Associated with hepatitis C, HHV-8

Question 28

Erythema nodosum is associated with what 7 conditions?

Answer 28

sarcoidosis, coccidioidomycosis, histoplasmosis, TB, streptococcal infections, leprosy , Crohn disease

Question 29

Which environmental derm issue can lead to impetigo?

Answer 29

Sunburn

Question 30

Exotoxin destroys keratinocyte attachments in --- only vs. toxic epidermal necrolysis, which destroys ---.

Answer 30

stratum granulosum epidermal-dermal junction

Question 31

--- is dominant in tanning and photoaging, --- in sunburn.

Answer 31

UVA UVB

Question 32

“palisading” nuclei is see in: "pseudopalisading” nuclei is seen in:

Answer 32

Basal cell tumors, Schwanomas Glioblastoma multiforme, Neuroblastoma

Question 33

Ulcerative red lesions, associated with scaling describes what pathology?

Answer 33

Squamous cell carcinoma ( assoc with actinic ketatosis)

Question 34

looks like squamous cell carcinoma that grows rapidly (4–6 weeks) and may regress spontaneously over months.

Answer 34

Kerato acanthoma

Question 35

Paths that are S-100?

Answer 35

Langerhans cell histiocytosis Schwannoma Melanoma

Question 36

keratin “pearls" seen in 2 paths?

Answer 36

Squamous cell carcinoma of lung Squamous cell carcinoma of skin

Question 37

Pink, pearly nodules, commonly with ---, rolled borders and central crusting or ulceration describes what path?

Answer 37

telangiectasias Basal cell carcinoma (pears on the base of ocean)

Question 38

Which scaly plaque is precursor to squamous cell carcinoma?

Answer 38

Actinic keratosis

Question 39

BRAF gene mutation is seen in what 4 paths?

Answer 39

* Serrated polyps * non Hodgkins lymphoma * hairy cell leukemia * Papillary carcinoma of thyroid * Melanoma * Letterer-siwe ( type of Langerhans cell histiocytosis)

Question 40

At what diameter can we call a lesion melanoma?

Answer 40

\>6 mm

Question 41

Metastatic or unresectable melanoma in patients with --- mutation can be treated with vemurafenib.

Answer 41

BRAF V600E (valine to glutamate)

Question 42

Name 4 types of melanoma?

Answer 42

superficial spreading nodular - worst lentigo maligna - older, multinucleated melanocytes acral lentiginous - on feet or palmer surface

Question 43

Deposits of IgA at tips of dermal papillae is seen in what blistering skin disorder? What type of HS?

Answer 43

Dermatitis herpetiformis HS type III

Question 44

What blistering skin disorder shows immunofluorescence of antibodies around epidermal cells in a reticular (net-like) pattern?

Answer 44

Pemphigus vulgaris

Question 45

Apoptosis of keratinocytes is seen in what skin disorder?

Answer 45

sunburn

Question 46

Erythema nodosum is lesion of what?

Answer 46

painful inflammatory lesions of subcutaneous fat