Antifungal 1 Flashcards Preview

Pharm Exam 2 > Antifungal 1 > Flashcards

Flashcards in Antifungal 1 Deck (50)
Loading flashcards...
31

mechanistically, what does the 5FU do?

Elimination of F+ is impossible b/c Fluorine is the most electronegative element

 

**functions as ANTIMETABOLITE

 

32

incorported into RNA in place of uracil

5-fluorouracil

Due to vanderwall radius similarity of F & H

33

5FU is also used as a ___ in humans

Anti-cancer agent

34

5 fluorocytosine is used with ___ to treat ___ infections

AmpB 

Candida and Crypto meningitis

35

High level of ____ to 5 FC

resistance

 

**administration with AmpB can kill resistant strains when they emerge

36

Whats one of the mechanisms of synergy between AmpB and 5FC

AmpB increases permeability of fungal cells

 

enhanes uptake of 5FC

37

5FC toxicity: main concern

bone marrow suppression

leads to leukopenia and thrombocytopenia

38

Ketoconazole ROA and use

Oral

Systemic infetions (blasto, histo, coccidio, paracoc)

39

Ketoconazole vs AmpB

Keto is tolerated better but is less effective

40

Fluconazole is a ______ (as opposed to a ____)

Triazole (3N's in a 5 membered ring)

Imidizole (2N's)

41

Fluconazole penetrates well into _____

the CNS

makes it appropriate for fungal meningitis

42

Fluconazole is first line for...

prevention of relapse of crypto meningitis in AIDS patients (who recieved AmpB)

43

Fluconazole infrequently causes...

hepatotoxicity

44

Itraconazole composition

1-1-1-1 racemic mixture of 4 diastereomers

 

(its a triazole like fluconazole)

45

Itraconazole ineffective for ___

treating CNS infections - doesnt appear in CSF

 

**very heavily bound to plasma proteins and is bound in tissues

46

Itraconazole preferred over ketoconazole for ____

non-meningeal histoplasmosis

 

(also disseminated histo in AIDS patients who were given AmpB)

47

Itraconazole AE's

heart failure

hepatoxicity

DDI with other P450 drugs (contraindicated with Cisapride, pimozide, quinidine, and dofetilide)

 

48

Echinocandins MOA

inhibit 1,3-ß-glucan synthase 

Halts production of 1,3 B glucan for cell wall

49

Echinocandins spectrum

 

Synergistic with what others?

Broad spec

 

Voriconazole

AmpB

50

Echinocandins ROA and AE's

IV

hepatotoxicity and hypersensitivity reactions