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Flashcards in Antimalarials Deck (38):
0

Tissue schizonticides

Primaquine
Atravaquone

1

Gametocide

Primaquine

2

Sporonticides

Proguanil
Pyrimethamine

3

Prevents polymerization of heme into hemozoin

Chloroquine

4

Complexes with DBA to prevent strand separation

Quinine

5

Unknown MOA

Mefloquine
Halofantrine

6

Forms electron transferring redox compounds that act as cellular oxidants

Primaquine

7

Disrupts mitochondrial ETC

Atovaquone

8

Inhibits folate synthesis

Proguanil

9

Sequential blocking of folic acid synthesis

Sulfadoxine-Pyrimethamine

10

Impairs progeny of malarial apicoplast genes resulting in abbormal cell division

Doxycycline

11

Forma toxic free radicals in malarial food vacuoles

Artemsinin

12

Antimalarial and DMARD

Chloroquine

13

Chloroquine may precipitate _

Porphyria

14

SE of quinine

Cinchonism

15

Triad of cinchonism

Headache
Tinnitus
Vertigo

16

Alternative to quinine in acute attacks of falciparum malaria

Mefloquine

17

Causes hemolysis in G6PD deficiency

Quinine
Primaquine

18

Decreased absorption with milk

Doxycycline
Tetracycline

19

Co-Atrem

Artemsinin + lumefantrine

20

Chemoprophylaxis for chloroquine-sensitive areas

Chloroquine

21

Chemoprophylaxis for chloroquine-resistant areas

Mefloquine
Atavaquone-proguanil

22

SE of primaquine

Methemoglobinemia
Hemolysis in G6PD deficiency

23

Competition for plasma protein binding sites with other drugs

Sulfadoxine-pyrimethamine

24

Chemoprophylaxis for multi-drug resistant malaria

Doxycycline

25

Treatment for uncomplicated falciparum

Artemsinin

26

May precipitate porphyria

Chloroquine

27

Can cause blackwater fever

Quinine

28

Should be used with a blood schizonticide

Primaquine

29

DOC for uncomplicated falciparum malaria in the Phil

Co-Artem

30

SE: cardiotoxicity. What kind?

Halofantrine
Prolongs PR and QT interval

31

SE: Myocardial depression, retinal damage, auditory impairment

Chloroquine

32

Quinine is commonly used with _ and _ to _

Doxycycline or clindamycin to limit toxicity

33

SE: folic acid deficiency

Pyrimethamine

34

SE: hepatotoxicity, nephrotoxicity, photosensitivity, vestibulotoxicity

Doxycycline

35

Teratogenic

Doxycycline (tooth enamel dysplasia/discoloration)
Halofantrine

36

Fatal complication of quinine-sensitized persons

Blackwater fever

37

Blocks DNA replication and transcription

Quinine