Other Antiprotozoal Drugs Flashcards Preview

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Flashcards in Other Antiprotozoal Drugs Deck (25):
0

Drugs for pneumocystosis and toxoplasmosis

Cotri
Pentamidine
Pyrethamine-Sulfadiazine

1

Blocks dihydropteroate synthase

Sulfamethoxazole
Sulfadiazine

2

Blocks dihydrofolate reductase

Timethoprim
Pyrimethamine

3

DOC for prophylaxis and treatment of pneumocystosis

Cotri

4

Backup for prophulais and treatment of pneumocystosis

Pentamidine

5

DOC for prophylaxis and treatment of toxoplasmosis

Pyrimethamine-sulfadiazine

6

Prophylaxis for T. gondii and isospora belli

Cotri

7

Mode of administration of pentamidine

Aerosol/nasal spray

8

SE: hematotoxicity (what kind?)

Pyrimethamine-sulfadiazine (megaloblastic anemia, thrombocytopenia)

9

Displaces protein binding of other drugs

Cotri

10

Drugs for West African sleeping sickness

Early: Pentamidine
CNS: Eflornithine

11

Drugs for East African sleeping sickness

Early: Suramin
CNS: Melarsoprol

12

Drugs for trypanosomiasis that cross the BBB

Melarsoprol
Eflornithine

13

Drugs for trypanosomiasis that do not cross the BBB

Suramin
Pentamidine

14

Used for kala-azar

Pentamidine

15

Back up drug for onchocerciasis

Suramin

16

Compare eflornithine and melarsoprol in terms of toxicity

Melarsoprol>>eflornithine

17

Suicide inhibitor of ornihine decarboxylase

Eflornithine

18

Organic arsenical. Inhibits enzyme sulfhydryl groups in trypanosomes

Melarsoprol

19

Inhibits trypanothione reductase

Nifurtimox

20

DOC for leishmaniasis

Sodium stinogluconate
(except in India - amphotericin B)

21

Causes anemia, neutropenia, hepatitis, pancreatitis

Pentamidine

22

Causes hemolytic anemia and agranulocytosis

Suramin

23

Causes reactive encephalopathy

Melarsoprol

24

Causes cardiotoxicity (what kind?)

Sodium stibogluconate (Twave changes, QT prolongation)