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Flashcards in DMARDs Deck (29):
0

Inhibits AICAR transformylase and thymidylate synthetase with secondary effects on PMN chemotaxis

Methotrexate

1

Forms phosphoramide mustard which crosslinks DNA to prevent cell replication

Cyclophosphamide

2

Binds to TNF-a and prevents it from activating TNF-a receptors

Infliximab

3

Suppression of T lymphocyte responses to mitogens

Chloroquine

4

Suppresses inosinic acid synthesis, B and T cell function, Ig production and IL2 secretion

Azathioprine

5

Decreases leukocyte chemotaxis

Chloroquine

6

Active metabolite inhibits releasenof inflammatory cytokines

Sulfasalazine

7

Stabilization of lysosomal enzymes, trapping of free radicals

Chloroquine

8

Inhibits IL1 and IL2 receptor production

Cyclosporin

9

Active metabolite inhibits inosine monophosphate drhydrogenase and Tcell lymphocyte proliferation

Mycophenolate mofetil

10

Active metabolite of sulfasalazine

Sulfapyridine

11

First choice to treat RA

Methotrexate

12

Rescue agent of cyclophosphamide

Mesna

13

Synergistic effect with methotrexate

Infliximab

14

Rescue agent for methotrexate

Leucovorin/folinic acid

15

Cannot give with azathioprine. Why?

Allopurinol
Can lead to leukopenia

16

Purine antimetabolite

Azathioprine

17

Safe for pregnant women

Chloroquine

18

SE: hemorrhagic cystitis

Cyclophosphamide secondary o acrolein

19

Causes psudolymphomatous reaction

Methotrexate

20

Causes reactivation of TB and HepB

Infliximab

21

SE: ocular toxicity

Chloroquine

22

Causes gingival hyperplasia

Cyclosporin

23

Causes reversible myelosuppression (neutropenia)

Mycophenolate mofetil

24

Causes reversible infertility in men

Sulfasalazine

25

Causes methemoglobinemia

Sulfasalazine

26

Treatment for Crohn's

Infliximab

27

Treatment for Behcet's

Azathioprine

28

Treatment for ankylosing spondylitis

Sulfasalazine