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Flashcards in Antimycobacterials Deck (39):
0

Nicotinic acid derivative

H

1

Butanol derivative

E

2

Inhibits mycolic acid synthesis

H

3

Inhibits DNA dependent DNA polymerase

R

4

Inhibits arabynosyl transferases involved in synthesis of arabinoglycan in mycobacterial cell wall

E

5

Unknown MOA

Z

6

Inhibit protein synthesis by binding to 30s subunit

S

7

Most important virulence factor of TB

Cord factor/trehalose mycolate

8

Bactericidal

HRS
Z (may be static)

9

SE of isoniazid

Hepatitis
Neurotoxicity
Hemolysis in G6PD
Drug-induced lupus

11

SE: red orange urine

R

12

SE: hepatotixicity

H

13

SE: color blindness (what kind?)

E (red green)

14

SE of Z

Hepatotoxicity
Hyperuricemia

16

For TB prophylaxis

H

17

Prophylaxis for meningococcal and staphylococcal carrier states

R

18

Coverage of streptomycin

TB
Tularemia
Bunonic plague
Brucellosis

19

Most important drug in TB

H

20

Potent CYP450 inducer

R

21

Most hepatitixic anti-TB drug

Z

24

Potent CYP450 inhibitor

H

25

Prevent neurotixicity of H by co-administering _

Pyridoxine

26

Administered IM

S

27

Aka sterilizing agent

Z

28

For S-resistant or MDR strains

Amikacin

29

Active against strains of M. tb resistant to first line agents

Cipro, oflox

30

Sulfone

Dapsone

31

Phenazine dye

Clofazimine

32

Inhibits folic acid synthesis

Dapsone

33

Ninds to guanine bases in bacterial DNA

Clofazamine

34

Most active drug against M. leprae

Dapsone

35

SE of dapsone

Methemoglobinemia
Hemolysis in G6PD

36

Dapsone is usually used in combination with _

Rifampicin and clofazimine

37

Prophylaxis for atypical mycobacteria

Clarithro/azithro +/- rifabutin if CD4<50

38

Treatment for atyoical mycobacteria

Azithro/clarithro + ethambutol + rifabutin

39

Bacteriostatic but can be bactericidal

Z

41

Rapid development of resistance if used alone

R

42

Bacteriostatic

E
Z (may be cidal)

44

SE of S

Nephrotoxicity (reversible)
Ototoxicity (irreversible)
Teratogenic (congenital deafness)