Flashcards in antimetabolites Deck (9):
sulfa: interferes with bacterial folic acid metabolism via inhibition of DHFA reduction from PABA
trimetho: inhibits DHFA reduction resulting in sequential inhibition of enzymes of the folic acid path
lower affinity of dihydropteroate sythesis for sulfonamides. decreased bacterial permeability or active efflux, alternative metabolic path for synthesis, increased production essential metabolite.
positive: MRSA/MSSA, s. pneumoniae, listeria. negative: enterobacter (ecoli, klebsiella, enterobacter), stenotrophomonas (DOC). toxo, nocardia, pneumocystis,
does this work on anaerobes
pneumocystis jirovecii, toxo encephalitis, UTI, listeria meningitis, MRSA.
rash (SJS, TEN), bone marrow suppression, renal (pseudofailure, AIN, hyperkalemia)
what is unique about trimeth-sulfa with the kidney
it acts as a K+ sparing diuretic.