Flashcards in antimetabolites Deck (9):
1
agents
trimethoprim-sulfamethoxazole (bactrim)
2
mechanism
sulfa: interferes with bacterial folic acid metabolism via inhibition of DHFA reduction from PABA
trimetho: inhibits DHFA reduction resulting in sequential inhibition of enzymes of the folic acid path
3
resistance
lower affinity of dihydropteroate sythesis for sulfonamides. decreased bacterial permeability or active efflux, alternative metabolic path for synthesis, increased production essential metabolite.
4
spectrum
positive: MRSA/MSSA, s. pneumoniae, listeria. negative: enterobacter (ecoli, klebsiella, enterobacter), stenotrophomonas (DOC). toxo, nocardia, pneumocystis,
5
does this work on anaerobes
no
6
clinical
pneumocystis jirovecii, toxo encephalitis, UTI, listeria meningitis, MRSA.
7
adverse
rash (SJS, TEN), bone marrow suppression, renal (pseudofailure, AIN, hyperkalemia)
8
what is unique about trimeth-sulfa with the kidney
it acts as a K+ sparing diuretic.
9