oxazolidinones Flashcards Preview

pharmacology unit 6 > oxazolidinones > Flashcards

Flashcards in oxazolidinones Deck (9):
1

agents

linezolid, tedizolid

2

mechanism of action

bind to 23s rRNA of the 50s subunit and inhibits sythesis

3

resistance

rare. through mutation

4

spectrum

gram (+): s. aureus (MRSA, MSSA), enterococcus (VRE), coagulat (-) staph, streptococci.

5

does this work against gram (-)

no

6

does this work against anaerobes

poorly

7

clinical uses

gram (+) alternative. VRE

8

adverse for linezolid

reversible myelosuppression. thrombocyto common. usually after 2 weeks of therapy

9

drug intereactions

reversible inhibitor of MOA. can result in serotonin syndrome