macrolides Flashcards Preview

pharmacology unit 6 > macrolides > Flashcards

Flashcards in macrolides Deck (8):
1

agents

azithromycin, erythromycin, calrithromycin

2

mechanism of action

reversible interaction with the 50s subunit of the ribosome.

3

resistance to the macrolides

decreased permeability (enterobacter), alteration in the binding site, enzymatic inactivation, alteration in the 23s ribosomal subunit.

4

spectrum of the macrolides

atypicals (legionella, chlamydia, mycoplasma); gram (+): s. pneumoniae; gram (-): h flu, catarrhalis; anaerobes: actinomyces.

5

clinical uses

uncomplicated U/L-RTI, mycobacterial infections (avium), h. pylori

6

adverse affects

GI (E>C>A), hepatic events are rare. QT prolongation,

7

drug interactions

clarithromycin and erythromycin potent inhibitors of CYP3A.

8

course of treatment

short, due to azythromycins long half life.