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Flashcards in glycyclines Deck (8):
1

what is the agent

tigecycline

2

what is the mechanism

derivative of minocycline that enhances ribosomal permeation and binding. it overcomes the efflux pump and ribosomal protection. lk

3

is this drug bacteriocidal

no its bacteriostatic because the interaction with the ribosome is reversible

4

spectrum

broad. negative, positive, anaerobes, includes MRSA, VRE, acinetobacter. atypicals.

5

what does this not treat

providencia, proteus, pseudomonas.

6

clinical uses

complicated skin infections and soft tissue, intra-abdominal, MDR infections (CRE),

7

what are the adverse affects

GI nausea/vomiting, diarrhea, increased LFTs,

8

what is this not used for?

bacteremia due to its tissue distribution, there is actually a low concentration in the serum.