Flashcards in glycyclines Deck (8):
what is the agent
what is the mechanism
derivative of minocycline that enhances ribosomal permeation and binding. it overcomes the efflux pump and ribosomal protection. lk
is this drug bacteriocidal
no its bacteriostatic because the interaction with the ribosome is reversible
broad. negative, positive, anaerobes, includes MRSA, VRE, acinetobacter. atypicals.
what does this not treat
providencia, proteus, pseudomonas.
complicated skin infections and soft tissue, intra-abdominal, MDR infections (CRE),
what are the adverse affects
GI nausea/vomiting, diarrhea, increased LFTs,