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Flashcards in cyclic lipopeptide Deck (10):
1

what is the only agent

daptomycin

2

what is the mechanism of action

insertion into the gram (+) cell membrane causing depolarization and ultimately ddeath

3

spectrum

MRSA, MSSA, coagulase negative staph, enterococcus (VRE), streptococci.

4

does this work against gram -

no

5

does this work against anaerobes

no

6

what are the uses for this

alternative to vancomycin, VRE infection

7

what are the adverse effects

myalgias, rhabdomyolysis, eosinophilic pneumonia

8

is there resistance?

yes, but rare.

9

is this effective for pulmonary infections

no. surfactant inactivates it.

10

does this penetrate the CSF

poorly.