cyclic lipopeptide Flashcards
1
Q
what is the only agent
A
daptomycin
2
Q
what is the mechanism of action
A
insertion into the gram (+) cell membrane causing depolarization and ultimately ddeath
3
Q
spectrum
A
MRSA, MSSA, coagulase negative staph, enterococcus (VRE), streptococci.
4
Q
does this work against gram -
A
no
5
Q
does this work against anaerobes
A
no
6
Q
what are the uses for this
A
alternative to vancomycin, VRE infection
7
Q
what are the adverse effects
A
myalgias, rhabdomyolysis, eosinophilic pneumonia
8
Q
is there resistance?
A
yes, but rare.
9
Q
is this effective for pulmonary infections
A
no. surfactant inactivates it.
10
Q
does this penetrate the CSF
A
poorly.
