glycopeptides

Question 1

vancomycin mechanism of action

Answer 1

binds to the D-ala-D-ala terminus of the nascent peptidoglycan pentapeptide. inhibits transglycosylase preventing the elongation of the peptidoglycan and cross-linking

Question 2

spectrum for vancomycin

Answer 2

gram (+): MRSA, MSSA (less sensitive betas), enterococcus, coagulase (-) staph (DOC), strep.

Question 3

does vancomycin work on gram (-)

Answer 3

no.

Question 4

does vancomycin work on b fragalis

Answer 4

no

Question 5

what anaerobes does vanco work on?

Answer 5

clostridium (including diff).

Question 6

what are mechanisms of resistance

Answer 6

target modification (enterococcus), trapping in the cell wall (staph makes a thicker wall when mutated), VRSA uses a vector to and uses target modification.

Question 7

what are the clinical uses for vancomycin

Answer 7

MRSA (skin, soft tissue, pneumonia, meningitis). C. diff, coagulase negative staph, MSSA with penicillin allergy

Question 8

what are the adverse affects from vanco

Answer 8

renal dysfunction, HSR (rash, hives), red mans syndrome

Question 9

what is red mans syndrome

Answer 9

histamine mediated (not allergic). stopped by slowing infusion

Question 10

what is the downfall of vanco?

Answer 10

bulky and poorly penetrates the BBB and lungs. but still effective.