Antimicrobial Therapy - Residues Flashcards Preview

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Flashcards in Antimicrobial Therapy - Residues Deck (7)
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1

Pharmacokinetics

Absorption - route of administration
Distribution - lipophilicity, barriers, kPa
Activation - some medicines need this
Metabolisation - breakdown products
Clearance - bile, urine (sweat, breath)

2

Cascade

7 days for milk
28 days for meat

3

Enrofloxacin (Baytril®) - when not to use

birds producing eggs for human consumption
layer replacement birds within 14 days of coming into lay

4

Chloramphenicol - when not to use

Aplastic Anaemia, 1 in 20,000, especially after oral
consumption
Bone marrow suppression
Very lipophilic

5

Metronidazole - when not to use

Carcinogenic
Not for food producing animals

6

testing for residues - Milk

mainly beta-lactam, done at the dairy

7

testing for residues - Meat

kidney test, done at abbatoir in case of suspicion and targeted surveillance