Haematology Flashcards Preview

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Flashcards in Haematology Deck (23):
1

indications - erythrocytes

anaemia
erythrocytosis

2

indications - leukocytes

infl conditions
neoplastic conditions
chemotherapy

3

indications - platelets

bleeding disorders
DIC

4

indications - plasma

colour

5

Packed cell volume

allows buffy coat assessment
plasma - clear/straw or pink if haemolysed
total protein measurement

6

CBC - erythrocytes

RBC conc
HGB - total haemoglobin
HCT - hematocrit + spun PCV
MCV - mean cell volume
MCH - mean cell haemoglobin
MCHC - mean cell haemoglobin conc
RDW - red cell distribution width

7

how to classify anemia

mild, moderate, severe
MCV - normo/micro/macrocytic
HCHC - normo/hyochromic (RBC conc)
regenerative or non

8

MCV - mean cell volume

average volume of a single cell

9

normocytic

RBCs of unremarkable size
often associated with mild non-regenerative anemia, acute haemorrhage

10

microcytic

red cell haemoglobin conc determines when division stops - Fe deficiency allows 1 more division - smaller RBCs
PSS, Fe deficiency, hepatic failure
akitas (breed)

11

macrocytic

in regeneration - polychromatophils larger the mature reds
some poodles

12

normo/hypochromic

haemoglobin conc
MCHC/MCH on panel
decreased in iron deficiency/poor iron incorporation

13

hyperchromic

not possible - haemolysis

14

regenerative anaemia

haemolysis
haemorrhage

15

non-regenerative anaemia

anaemia of infl/chronic disease
chronic renal failure
decreased production in marrow

16

reticulocytes

on diif-quik or giemsa stains young cells with ribosomal RNA show up larger, bluer cells - polychromatophils
same cells stained with new methylene blue and the RNA precipitates forming aggregates/reticulum - reticulocytes

17

reticulocytes in cats

released as aggregate retics, mature to punctate retics over time

18

RBC morphology

spherocytes, ghost cells
hypochromasia/leptocytosis
shear products
oxidative damage
organisms

19

components of a CBC (complete blood count)

total white blood cells (WBC)
neutro/eosino/basophils
lympho/monocytes

20

leukocytes

normal - 100 cells/10x10*9/L
morphology - neutrophils - left shift, toxicity

21

left shift classification

regenerative left shift - neutrophilia, segmented > bands
degenerative left shift - neutropenia, bands > segmented

22

acute leukemias

blast cells in circulation
much more likely to be lymphoid
if signs of segmentation - myeloid, myelomonocytic
immunophenotyping - flow cytometer

23

chronic leukemias

CLL - lymphocytes appear small, mature - persistent high numbers
CML - neutrophils appear normal - persistent high numbers