Antiseizure Medication Flashcards Preview

Pharmacology > Antiseizure Medication > Flashcards

Flashcards in Antiseizure Medication Deck (38):
1

Name 5 Classes of antiseizure medication:

1. Benzodiaepines
2. Barbiturates
3. Hydontioin
4. Phenytoin-like drug
5. Succinimide

2

Name 2 drugs in Benzodiazepine class

1. Ativan
2. Valium

3

Mechanism of action for Benzo

Change action of GABA

4

What do benzo's Tx?

Short-term seizures

5

Adverse effects for Benzo

1. PNS reaction
2. Drowsiness
3. Respiration depression

6

Name 1 medication in Barbiturate class

Luminal

7

Mechanism of action for barbiturate

Changes action of GABA

8

Barbiturates Tx...?

Seizures

9

Adverse effects for barbiturates

1. Dependence
2. Drowsiness
3. Vitamin deficiency

10

RN Implication for barbiturates

1. Last resort medication
2. Monitor liver & kidney fxn
3. Pregnancy D class

11

Name 1 Rx in Hydontoin class

Dilantin

12

Mechanism of action for Dilantin

Desensitizes Na+ channels

13

What does Dilantin Tx?

Epilepsy except absence seizures

14

Adverse effects for dilantin

1. CNS depression
2. Gingivial Hyperplasia
3. Hypotension

15

RN Implications for dilantin & Teaching

1. Monitor blood
2. Monitor kidney & liver fxn
3. Report excessive bleeding
4. Maintain good oral hygeine

16

Name 2 pheytoin-like meds

1. Depakene
2. Depakote

17

Mechanism of action for Depakote

Desensitizes Na+ channels

18

What does Depakote Tx?

Absence seizures

19

Adverse effects of depakote

1. Visual disturbances
2. Ataxia
3. Vertigo
4. GI upset

20

RN Implications for depakote

1. Avoid alcohol & Smoking
2. Rebound seizures occur if stopped abruptly
3. Take c food

21

Name 1 medication from Succinimide class

Zorantin

22

Mechanism of action of Zorantin

Suppresses CA+ influx

23

Zorantin Tx what?

Absence seizures

24

Adverse effects for Zorantin

1. Drowsiness
2. Dizziness
3. Lethargy

25

RN Implication & Teaching

1. Pregnancy C
2. Severe mental depression
3. Take c food

26

Seizures are clinically detectable sign of epilepsy

1. Abnormal or uncontrolled neuronal discharges in the brain
2. Affect:
a. Consciousness
b. Motor activity
c. Sensation
3. Symptom of an underlying disorder

27

What is the definition of epilepsy

Epilepsy is a disorder that results from the surges in electrical signals inside the brain, causing recurring seizures

28

Convulsion

Involuntary violent spasm of large muscles

29

Known causes of seizures or epilepsy

1. Infectious disease
2. Trauma
3. Metabolic disorder
4. Vascular disease
5. Pediatric disorder
6. Neoplastic disease

30

Epilepsy

Seizures occurring chronically

31

Classification of epilepsy

1. Partial= 1 side of the brain
2. Generalized=both sides of the brain
3. Special epileptic syndrome

32

Pregnancy & Epilepsy

1. Antiseizure medications decrease effectiveness of oral contraceptives
2. Most antiseizure Rx are pregnancy category D

33

Status Epilepticus

1. Considered a medical emergency
2. Continuous seizure activity, which can lead to coma & death

34

Choice of seizure med depends on

1. Type of seizure
2. Pt Hx * Dx studies
3. Associated pathologies

35

Once medication is selected

1. Pt is placed on low initial dose
2. Gradually increased
3. If seizure activity remains, different medication added in small increments

36

Antiseizure pharmacotherapy goal

Suppress neuronal activity enough to prevent abnormal or repetitive firing

37

Antiseizure medication mechanism of action

1. Stimulating influx of Ch-
2. Delaying an influx of Na+
3. Delaying an influx of Ca++

38

W/D from antiseizure medication

1. Seizure free for @ least 3 years
2. W/D gradualy over several months
3. Resume medication if seizures return
4. Rebound seizures may occur